Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026935 | 0.76 | NPC1 (0.51) | THRBTHRAMAPK1L3MBTL1 | |
| SCHEMBL819105 | 0.75 | THRB (0.56) | THRBTHRALMNAMAPK1L3MBTL1 | |
| SCHEMBL583230 | 0.75 | RAB9A (0.48) | LMNAMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL30197447 | 0.75 | THRB (0.56) | THRBTHRALMNAMAPK1L3MBTL1 | |
| SCHEMBL3841280 | 0.74 | THRB (0.56) | THRBTHRAMAPK1KDM4EALDH1A1 | |
| SCHEMBL29413361 | 0.74 | THRB (0.56) | THRBTHRAMAPK1KDM4EALDH1A1 | |
| SCHEMBL28991775 | 0.73 | THRB (0.57) | THRBTHRALMNAL3MBTL1KDM4E | |
| SCHEMBL28924976 | 0.72 | KMT2A (0.52) | THRBTHRALMNAL3MBTL1KDM4E | |
| SCHEMBL27368181 | 0.72 | THRB (0.49) | THRBTHRAPDE6DMAPK1MAP3K7 | |
| SCHEMBL2235806 | 0.70 | THRA (0.53) | THRBTHRALMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213666-B1 | LIGUSTRAZINE AROMATIC ACID ETHER DERIVATIVE, ITS PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION | LI JIAMING (CN) | 2012-02-15 | — | — | EP | disclosed |
| EP-2213666-A1 | LIGUSTRAZINE AROMATIC ACID ETHER DERIVATIVE, ITS PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION | Li, Jiaming (CN) | 2010-08-04 | — | — | EP | disclosed |