Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 7/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | LONP1 | P36776 | 5/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 5/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5833028 | 0.92 | MMP8 (0.45) | MMP9MMP8PSMB5CTSLPSMB8 | |
| SCHEMBL5833850 | 0.90 | CTSL (0.49) | MMP9MMP8MMP12PSMB5CTSL | |
| SCHEMBL5833547 | 0.86 | GPR132 (0.50) | MMP9MMP8CTSLCTSBREN | |
| SCHEMBL5833543 | 0.86 | GPR132 (0.50) | MMP9MMP8CTSLCTSBREN | |
| SCHEMBL5833288 | 0.85 | MMP9 (0.44) | MMP9MMP8MMP12PSMB5CTSL | |
| SCHEMBL5833193 | 0.85 | MMP12 (0.46) | MMP9MMP8MMP12PSMB5CTSL | |
| SCHEMBL5833528 | 0.84 | ACACB (0.50) | CTSLCTSBRENKDM4E | |
| SCHEMBL5833526 | 0.82 | MMP9 (0.44) | MMP9MMP8MMP12PSMB5CTSL | |
| SCHEMBL5832730 | 0.81 | GPR132 (0.43) | PSMB5CTSLCTSBRENKDM4E | |
| SCHEMBL5832907 | 0.81 | ACACB (0.49) | CTSLCTSBRENKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030060419-A1 | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers | HU LAIN-YEN (US) | 2003-03-27 | — | — | US | claimed |
| US-6166052-A | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers | WARNER-LAMBERT COMPANY (US) | 2000-12-26 | — | — | US | claimed |
| US-6989448-B2 | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers | HU LAIN-YEN | 2006-01-24 | — | — | US | disclosed |
| US-20030060419-A1 | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers | HU LAIN-YEN (US) | 2003-03-27 | — | — | US | disclosed |
| US-6469038-B1 | CALCIUM CHANNEL BLOCKERS THAT CAN BLOCK N-TYPE CALCIUM CHANNELS AND CAN BE USED TO TREAT STROKE, PAIN, CEREBRAL ISCHEMIA, HEAD TRAUMA, ASTHMA, AMYOTROPIC LATERAL SCLEROSIS, AND EPILEPSY | WARNER-LAMBERT COMPANY | 2002-10-22 | — | — | US | disclosed |
| US-6166052-A | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers | WARNER-LAMBERT COMPANY (US) | 2000-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060419-A1 | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers | CACNA1C, CACNA1I, CACNA1S | MMP9 1991/4885MMP8 2960/4885MMP12 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.