Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.69 |
| ▸ | ACP1 | P24666 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.59 |
| ▸ | SCD | O00767 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | WNT3A | P56704 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962875 | 0.86 | CCNE1 (0.66) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL69753 | 0.84 | CCNE1 (0.74) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL70693 | 0.82 | CCNE1 (0.63) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL5840422 | 0.81 | KDR (0.72) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL21484795 | 0.80 | CCNE1 (0.67) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL5835965 | 0.78 | LMNA (0.65) | CCNE1CDK2CDK5ALDH1A1MEN1 | |
| SCHEMBL21962874 | 0.78 | KDR (0.60) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL17014785 | 0.78 | KDR (0.68) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL10252594 | 0.78 | KDR (1.00) | CCNE1CDK2CDK5ACP1KDR | |
| SCHEMBL2256136 | 0.78 | KDR (0.72) | CCNE1CDK2CDK5ACP1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |