Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | LTA4H | P09960 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.59 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | P4HB | P07237 | 1/20 | 0.53 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4100319 | 0.92 | HPGD (0.83) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL13599772 | 0.92 | MAPT (0.83) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL755167 | 0.92 | MAPT (0.83) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL14198677 | 0.87 | MAPT (0.73) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL12372650 | 0.87 | MAPT (0.73) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL14407928 | 0.87 | MAPT (0.73) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL25873962 | 0.87 | LTA4H (0.73) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL18978085 | 0.87 | LTA4H (0.73) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL19018299 | 0.87 | LTA4H (0.73) | MAPTRAB9ALTA4HHPGDPARP10 | |
| SCHEMBL12372656 | 0.87 | MAPT (0.73) | MAPTRAB9ALTA4HHPGDPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119201-B2 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC (US) | 2006-10-10 | — | — | US | disclosed |
| US-20040006057-A1 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER PRODUCTS INC. | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006057-A1 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | MMP8, MMP9, MMP1 | MAPT 4575/4885RAB9A 4021/4885LTA4H 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.