Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.33 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL7050319 | 0.94 | CHRM1 (0.36) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Methacrylic Acid SCHEMBL591806 | 0.81 | ALPL (0.37) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Methacrylic Acid SCHEMBL7906126 | 0.81 | HPGD (0.41) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Acrylic Acid SCHEMBL10610466 | 0.80 | ALPL (0.38) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Methacrylic Acid SCHEMBL17003962 | 0.79 | HPGD (0.39) | CHRM4CHRM1CHRM3CHRM2POLB | |
| SCHEMBL10883968 | 0.77 | CHRM1 (0.45) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Styrene SCHEMBL11315893 | 0.77 | TSHR (0.42) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Acetic Acid SCHEMBL7939756 | 0.76 | ALPL (0.41) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Bicarbonate SCHEMBL9180912 | 0.74 | ALPL (0.42) | CHRM4CHRM1CHRM3CHRM2POLB | |
| Ethylene Glycol SCHEMBL4653120 | 0.74 | TRPA1 (0.38) | CHRM4CHRM1CHRM3CHRM2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087748-B2 | Process | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-08-08 | — | — | US | disclosed |
| US-20040063930-A1 | Selective adsorption | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063930-A1 | Selective adsorption | GMPS, ITPA, TET2 | CHRM1 240/4885CHRM3 818/4885CHRM2 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.