Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676015 | 0.96 | CYP3A4 (0.54) | CYP3A4SMN1; SMN2ALDH1A1RECQLLTA4H | |
| SCHEMBL7747383 | 0.94 | LTA4H (0.58) | CYP3A4SMN1; SMN2ALDH1A1RECQLLTA4H | |
| SCHEMBL12669344 | 0.91 | APP (0.51) | CYP3A4SMN1; SMN2ALDH1A1RECQLLTA4H | |
| SCHEMBL225915 | 0.90 | NOS1 (0.50) | CYP3A4SMN1; SMN2ALDH1A1LTA4HNOS1 | |
| SCHEMBL14548566 | 0.89 | MAOB (0.66) | CYP3A4SMN1; SMN2MAOBPPARA | |
| SCHEMBL5320737 | 0.89 | APP (0.53) | CYP3A4SMN1; SMN2ALDH1A1LTA4HNOS1 | |
| SCHEMBL7752472 | 0.88 | GAA (0.66) | CYP3A4SMN1; SMN2ALDH1A1MAOBNR1I2 | |
| SCHEMBL10606350 | 0.88 | CYP3A4 (0.62) | CYP3A4SMN1; SMN2ALDH1A1RECQLLTA4H | |
| SCHEMBL2088711 | 0.86 | NOS1 (0.52) | CYP3A4SMN1; SMN2ALDH1A1LTA4HNOS1 | |
| SCHEMBL8956052 | 0.86 | NOS1 (0.52) | CYP3A4SMN1; SMN2ALDH1A1LTA4HNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409658-B9 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2024-07-17 | — | — | EP | disclosed |
| EP-3409658-B1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2024-03-06 | — | — | EP | disclosed |
| EP-4326708-A1 | GPR35 AGONIST COMPOUNDS | Heptares Therapeutics Limited (GB) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022224212-A1 | GPR35 AGONIST COMPOUNDS | HEPTARES THERAPEUTICS LIMITED (GB) | 2022-10-27 | — | — | WO | disclosed |
| WO-2022224212-A1 | GPR35 AGONIST COMPOUNDS | HEPTARES THERAPEUTICS LIMITED (GB) | 2022-10-27 | — | — | WO | disclosed |
| US-10730830-B2 | Tetrahydronaphthalene derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-08-04 | — | — | US | disclosed |
| US-20190031605-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-01-31 | — | — | US | disclosed |
| EP-3409658-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO Pharmaceutical Co., Ltd. (JP) | 2018-12-05 | — | — | EP | disclosed |
| EP-2914597-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2017-12-06 | — | — | EP | disclosed |
| US-20170298051-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | THE UNIVERSITY OF TOKYO (JP) | 2017-10-19 | — | — | US | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060235075-A1 | Analogous compounds of strobilurines and their use as acaricides and insecticides | ISAGRO RICERCA S.R.L. (IT) | 2006-10-19 | — | — | US | disclosed |
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| WO-2005095330-A1 | NOVEL DICHLOROPROPENE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2005-10-13 | — | — | WO | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235075-A1 | Analogous compounds of strobilurines and their use as acaricides and insecticides | DDT, RYR1, TPMT | CYP3A4 148/4885SMN1; SMN2 257/4885ALDH1A1 13/4885 |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | CYP3A4 1683/4885SMN1; SMN2 3985/4885ALDH1A1 355/4885 |
| US-10730830-B2 | Tetrahydronaphthalene derivative | S1PR5, S1PR1, GPR55 | CYP3A4 1977/4885SMN1; SMN2 937/4885ALDH1A1 1792/4885 |
| US-20170298051-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | ADIPOR1, ADIPOR2, CCKAR | CYP3A4 1711/4885SMN1; SMN2 4372/4885ALDH1A1 1802/4885 |
| US-20190031605-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | S1PR5, S1PR1, GPR55 | CYP3A4 1986/4885SMN1; SMN2 945/4885ALDH1A1 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.