Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30679979 | 0.79 | TBK1 (0.41) | CYP2C9HTTSLC40A1KDM4E | |
| SCHEMBL26115511 | 0.79 | TBK1 (0.41) | CYP2C9HTTSLC40A1KDM4E | |
| SCHEMBL6986883 | 0.78 | GLO1 (0.42) | COMTCYP2C9HTTGLO1ALOX15 | |
| SCHEMBL4026969 | 0.77 | ALOX15 (0.40) | COMTHTTGLO1ALOX15MAPK1 | |
| SCHEMBL4025246 | 0.77 | CYP2C9 (0.48) | COMTCYP2C9HTTGLO1ALOX15 | |
| SCHEMBL4028251 | 0.76 | CYP2C9 (0.58) | CYP2C9 | |
| SCHEMBL4043717 | 0.75 | CCR1 (0.41) | HTTGLO1SLC40A1MEN1KMT2A | |
| SCHEMBL2696188 | 0.74 | PSMD14 (0.62) | COMTHTTALOX15SLC40A1MEN1 | |
| SCHEMBL6605252 | 0.73 | MEN1 (0.39) | HTTGLO1ALOX15MAPK1CA1 | |
| SCHEMBL5778919 | 0.73 | GLO1 (0.37) | COMTCYP2C9HTTGLO1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7009055-B2 | such as (methyl-sulfonyl)methyl bromo-quinoline by treatment of dibromomethyl bromo-quinoline with sodium methanesulfinate in solvent; chemical intermediates in production of phosphodiesterase inhibitors | MERCK & CO., INC. (US) | 2006-03-07 | — | — | US | disclosed |
| US-20040176604-A1 | Preparation of sulfonyl quinoline | XU FENG (US) | 2004-09-09 | — | — | US | disclosed |
| WO-2003010137-A1 | PREPARATION OF SULFONYL QUINOLINE | MERCK & CO., INC. (US) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176604-A1 | Preparation of sulfonyl quinoline | STS, SULT2A1, BRD7 | COMT 1493/4885CYP2C9 2306/4885HTT 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.