Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15787085 | 0.77 | CA1 (0.55) | S1PR1S1PR3S1PR5MEN1KMT2A | |
| SCHEMBL15787076 | 0.77 | CA1 (0.55) | S1PR1S1PR3S1PR5MEN1KMT2A | |
| SCHEMBL15787077 | 0.77 | CA1 (0.55) | S1PR1S1PR3S1PR5MEN1KMT2A | |
| SCHEMBL10350829 | 0.76 | NPC1 (0.59) | SMN1; SMN2ALDH1A1KCNK3KCNK9SLC6A9 | |
| SCHEMBL5843534 | 0.75 | CTSL (0.85) | CTSLCTSSCTSK | |
| SCHEMBL10269450 | 0.74 | MEN1 (0.78) | SMN1; SMN2KCNK3KCNK9MEN1KMT2A | |
| SCHEMBL30739887 | 0.74 | MEN1 (0.78) | SMN1; SMN2KCNK3KCNK9MEN1KMT2A | |
| SCHEMBL28693506 | 0.74 | ALDH1A1 (0.65) | SMN1; SMN2TAS1R3TAS1R1ALDH1A1KCNK3 | |
| SCHEMBL1307149 | 0.73 | ITGB2 (0.47) | ALDH1A1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL17663832 | 0.73 | S1PR3 (0.73) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | disclosed |
| WO-2004084842-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
| US-20040198780-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198780-A1 | Inhibitors of cathepsin S | CTSS, CTSK, CTSE | SMN1; SMN2 3203/4885CTSL 10/4885CTSS 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.