Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802657 | 0.79 | ALDH1A1 (0.46) | ALDH1A1NOS2KDM4EPOLB | |
| SCHEMBL2632832 | 0.72 | ALDH1A1 (0.49) | ALDH1A1KMT2ANOS2ESR1L3MBTL1 | |
| SCHEMBL27724937 | 0.71 | ALDH1A1 (0.45) | ALDH1A1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL5844397 | 0.70 | PDK2 (0.39) | ALDH1A1KMT2ASIGMAR1HRH4HRH3 | |
| SCHEMBL20840575 | 0.69 | ALDH1A1 (0.50) | ALDH1A1KMT2AL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL1187597 | 0.69 | NOS2 (0.57) | NOS2HRH3ESR1ESR2NPSR1 | |
| SCHEMBL10496111 | 0.69 | NOS2 (0.45) | ALDH1A1SIGMAR1NOS2HRH4HRH3 | |
| SCHEMBL10627509 | 0.69 | NOS2 (0.45) | ALDH1A1SIGMAR1NOS2HRH4HRH3 | |
| SCHEMBL1187650 | 0.68 | KCNH2 (0.52) | ALDH1A1NOS2ESR1ESR2 | |
| SCHEMBL5844251 | 0.68 | L3MBTL1 (0.37) | ALDH1A1KMT2ASIGMAR1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125880-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-7067664-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-6956047-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| CN-1152021-C | Corticotropin release factors antagonistic agent | ������ҩ������˾ | 2004-06-02 | — | — | CN | disclosed |
| EP-0764166-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER (US) | 2000-09-13 | — | — | EP | disclosed |
| CN-1246475-A | Corticotropin release factors antagonistic agent | PFIZER (US) | 2000-03-08 | — | — | CN | disclosed |
| CN-1049659-C | Corticotropin releasing factor antagonists | PFIZER (US) | 2000-02-23 | — | — | CN | disclosed |
| US-5962479-A | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 1999-10-05 | — | — | US | disclosed |
| CN-1150428-A | Corticotropin releasing factor antagonists | PFIZER (US) | 1997-05-21 | — | — | CN | disclosed |
| EP-0764166-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER INC. (US) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995033750-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER INC. (US) | 1995-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032846-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | ALDH1A1 4423/4885KMT2A 3907/4885SIGMAR1 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.