Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15779490 | 0.92 | NPC1 (0.51) | SLC2A1NPC1RAB9AMAPTLTA4H | |
| SCHEMBL488951 | 0.83 | NPC1 (0.61) | NPC1RAB9AMAPTLTA4HMAPK14 | |
| SCHEMBL7843486 | 0.79 | LTA4H (0.56) | SLC2A1NPC1RAB9AMAPTLTA4H | |
| SCHEMBL5843589 | 0.77 | S1PR4 (0.49) | SLC2A1NPC1RAB9AMAPTLTA4H | |
| SCHEMBL7844990 | 0.77 | LTA4H (0.54) | SLC2A1NPC1RAB9AMAPTLTA4H | |
| SCHEMBL488813 | 0.77 | RAB9A (0.55) | NPC1RAB9AMAPTLTA4HMAPK14 | |
| SCHEMBL5845971 | 0.76 | LTA4H (0.68) | NPC1RAB9AMAPTLTA4HMAPK14 | |
| SCHEMBL14812299 | 0.76 | MET (0.54) | SLC2A1NPC1RAB9AMAPTLTA4H | |
| SCHEMBL11084194 | 0.75 | LTA4H (0.56) | NPC1RAB9AMAPTLTA4HMAPK14 | |
| SCHEMBL23850962 | 0.74 | LTA4H (0.54) | NPC1RAB9AMAPTLTA4HMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105534-B2 | Imidazo[1,2-α]pyridine ether compounds as ion channel modulators | CARDIOME PHARMA CORP. (CA) | 2006-09-12 | — | — | US | disclosed |
| US-20040048885-A1 | Imidazo[1,2,-A]pyridine ether compounds as ion channel modulators | CORREVIO CANADA CORP. (CA) | 2004-03-11 | — | — | US | disclosed |
| WO-2001096335-A1 | IMIDAZO[1,2-A]PYRIDINE ETHER COMPOUNDS AS ION CHANNEL MODULATORS | CARDIOME PHARMA CORP. (CA) | 2001-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048885-A1 | Imidazo[1,2,-A]pyridine ether compounds as ion channel modulators | KCNJ2, KCNH2, KCNA1 | SLC2A1 3839/4885NPC1 1322/4885RAB9A 1451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.