Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723081 | 0.92 | SIGMAR1 (0.64) | SIGMAR1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL3718831 | 0.86 | SIGMAR1 (0.60) | SIGMAR1MEN1KMT2APOLB | |
| SCHEMBL5845492 | 0.86 | ALDH1A1 (0.44) | SIGMAR1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL6526231 | 0.83 | POLB (0.47) | SIGMAR1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL9008678 | 0.79 | ACHE (0.65) | CYP1A2CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL10857838 | 0.76 | SIGMAR1 (0.69) | SIGMAR1MEN1KMT2APOLBMAPT | |
| SCHEMBL2568094 | 0.75 | MEN1 (0.56) | SIGMAR1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL6235061 | 0.75 | POLB (0.64) | CYP1A2CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL8568229 | 0.75 | SIGMAR1 (0.57) | SIGMAR1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL5063513 | 0.75 | POLB (0.64) | CYP1A2CYP2D6CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151118-B2 | Biphenylcarboxylic amide derivatives as p38-kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2006-12-19 | — | — | US | disclosed |
| US-20050020540-A1 | Biphenylcarboxylic amide derivatives as p38-kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020540-A1 | Biphenylcarboxylic amide derivatives as p38-kinase inhibitors | MAPK1, MAPKAPK2, MAP3K1 | SIGMAR1 1003/4885CYP1A2 540/4885CYP2D6 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.