Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063513 | 0.90 | POLB (0.64) | POLBMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL5054804 | 0.82 | POLB (0.54) | POLBMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL17387499 | 0.81 | KMT2A (0.47) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL7527710 | 0.77 | MEN1 (0.54) | POLBMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL5845501 | 0.75 | SIGMAR1 (0.56) | POLBMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL10426713 | 0.75 | KMT2A (0.43) | POLBMEN1KMT2ACYP2C19MAPT | |
| SCHEMBL8722296 | 0.75 | PARP1 (0.44) | POLBMEN1KMT2ACYP2C19MAPT | |
| SCHEMBL3723081 | 0.73 | SIGMAR1 (0.64) | POLBMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL5484250 | 0.72 | TSHR (0.44) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL17186886 | 0.72 | ALDH1A1 (0.42) | POLBMEN1KMT2ACYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |