SCHEMBL58461

SCHEMBL58461

CCc1cccc(N=C=O)c1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.50
GABRB2 P47870 1/20 0.50
SIGMAR1 Q99720 10/20 0.44
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
GRIN2C Q14957 1/20 0.44
GRIN3A Q8TCU5 1/20 0.44
CYP3A4 P08684 3/20 0.44
TSHR P16473 1/20 0.44
TRPA1 O75762 1/20 0.43
MAPK1 P28482 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MGLL Q99685 1/20 0.40
TP53 P04637 1/20 0.38
NOS1 P29475 1/20 0.38
BCL2 P10415 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22080193 0.87 CYP3A4 (0.44) GABRA1GABRB2SIGMAR1GRIN2DGRIN3B
SCHEMBL1357859 0.85 GRIN2D (0.47) GABRA1GABRB2SIGMAR1GRIN2DGRIN3B
SCHEMBL6805641 0.84 CYP3A4 (0.47) GABRA1GABRB2CYP3A4TSHRTRPA1
SCHEMBL29854874 0.84 CYP3A4 (0.57) GABRA1GABRB2CYP3A4TSHRTRPA1
SCHEMBL387552 0.84 CYP3A4 (0.57) GABRA1GABRB2CYP3A4TSHRTRPA1
SCHEMBL11608082 0.82 LPL (0.41) GABRA1GABRB2SIGMAR1GRIN2DGRIN3B
SCHEMBL17707285 0.81 SIGMAR1 (0.50) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL17707286 0.81 SIGMAR1 (0.50) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL27320613 0.81 LPL (0.47) GABRA1GABRB2TDP1
SCHEMBL1435119 0.81 GABRA1 (0.48) GABRA1GABRB2SIGMAR1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 348 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119875529-A Acid-base resistant UV (ultraviolet) adhesive-reducing tape and preparation method and application thereof 广州慧谷功能材料有限公司 2025-04-25 CN claimed
CN-118046638-A High-strength polyurethane metal surface sandwich board with improved sound insulation performance 山东北理华海复合材料有限公司 2024-05-17 CN claimed
CN-115610042-A Environment-friendly metal covering sandwich panel based on modified polyurethane 山东北理华海复合材料有限公司 2023-01-17 CN claimed
CN-115304739-A Preparation method of aerogel polyurethane composite thermal insulation material 山东北理华海复合材料有限公司 2022-11-08 CN claimed
US-10092881-B2 Permanent hydrophilic porous coatings and methods of making them BHA ALTAIR, LLC (US) 2018-10-09 US claimed
CN-106632940-A Polycarbodiimide compounds, preparation method thereof and liquid type hydrolysis-resistant agent composition 上海华峰新材料研发科技有限公司 2017-05-10 CN claimed
US-20090191399-A1 PERMANENT HYDROPHILIC POROUS COATINGS ONTO A SUBSTRATE AND POROUS MEMBRANES THEREOF GENERAL ELECTRIC COMPANY (US) 2009-07-30 US claimed
US-20090191398-A1 MEMBRANES COMPRISING HYDROPHILIC COATINGS GENERAL ELECTRIC COMPANY (US) 2009-07-30 US claimed
EP-1754705-A2 Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders Genentech, Inc. (US) 2007-02-21 EP claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
EP-4680252-A1 SYSTEM AND METHOD FOR FLUID CAPTURE GE Vernova Infrastructure Technology LLC (US) 2026-01-21 EP disclosed
EP-4680375-A1 SYSTEM AND METHOD FOR FLUID CAPTURE GE Vernova Technology GmbH (CH) 2026-01-21 EP disclosed
EP-4587158-A2 SYSTEM AND METHOD FOR FLUID CAPTURE USING A CROSS-LINKED BINDER General Electric Company (US) 2025-07-23 EP disclosed
US-20250186433-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF EPIVARIO, INC. 2025-06-12 US disclosed
CN-120091854-A System and method for capturing fluids using a cross-linked binder 通用电气技术有限公司 2025-06-03 CN disclosed
EP-0609306-A1 BENZODIAZEPINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF CHOLECYSTOKININ AND/OR GASTRIN RECEPTORS MERCK SHARP & DOHME LTD. (GB) 1994-08-10 EP disclosed
WO-1993008176-A1 BENZODIAZEPINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF CHOLECYSTOKININ AND/OR GASTRIN RECEPTORS MERCK SHARP & DOHME LIMITED (GB) 1993-04-29 WO disclosed
EP-0539170-A1 Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors MERCK SHARP & DOHME LTD. (GB) 1993-04-28 EP disclosed
US-4349685-A 5-Substituted-benzoxathiol-2-ones THE DOW CHEMICAL COMPANY (US) 1982-09-14 US disclosed
US-3937824-A COMPOSITIONS AND METHODS OF KILLING INSECTS AND ACARIDS USING ALKOXYIMINO CARBAMOYLOXY PHOSPHORUS COMPOUNDS VELSICOL CHEMICAL CORPORATION (US) 1976-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250186433-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF ACSS2, GLS2, ADSS2 GABRA1 4244/4885GABRB2 2988/4885SIGMAR1 3738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.