SCHEMBL5846489

SCHEMBL5846489

Cc1cc(C)cc(C(C)C(=O)Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TPMT P51580 1/20 0.39
PSEN1 P49768 1/20 0.38
PSEN2 P49810 1/20 0.38
APH1B Q8WW43 1/20 0.38
NCSTN Q92542 1/20 0.38
APH1A Q96BI3 1/20 0.38
PSENEN Q9NZ42 1/20 0.38
PTGS2 P35354 1/20 0.38
ALDH1A1 P00352 2/20 0.35
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32
ERN1 O75460 1/20 0.32
TAS1R3 Q7RTX0 1/20 0.31
TAS1R1 Q7RTX1 1/20 0.31
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27774456 0.81 TPMT (0.42) TPMTPSEN1PSEN2APH1BNCSTN
SCHEMBL2153144 0.79 ACP3 (0.46) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL8960142 0.79 PTGS2 (0.54) TPMTPTGS2ALDH1A1CYP1A2TSHR
SCHEMBL5846200 0.79 PTGS2 (0.54) TPMTPTGS2ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL5846495 0.77 PTGS2 (0.53) TPMTPTGS2ALDH1A1CYP1A2TSHR
SCHEMBL4432428 0.77 TPMT (0.39) TPMTPSEN1PSEN2APH1BNCSTN
SCHEMBL27964908 0.77 EPHX1 (0.46) TPMTPSEN1PSEN2APH1BNCSTN
SCHEMBL2415101 0.77 ALOX5 (0.46) PTGS2ALDH1A1MEN1KMT2A
SCHEMBL28175905 0.77 TPMT (0.39) TPMTPTGS2ALDH1A1HTTNPSR1
SCHEMBL27713992 0.75 TPMT (0.46) TPMTALDH1A1HTTNPSR1RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7012138-B1 Chiral polysaccharide esters, one of the methods for preparing them and their uses for obtaining optically enriched acids or for chiral chromatography UNIVERSITE DE DROIT D'ECONOMIE ET DES SCIENCES D'AIZ-MARSEILLE (FR) 2006-03-14 US disclosed