Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.53 |
| ▸ | CTSG | P08311 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | CTRC | Q99895 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | EP300 | Q09472 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770320 | 1.00 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1749140 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1749922 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL651980 | 0.89 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL13783795 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL1023519 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL12372537 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL8572187 | 0.82 | MT-CO2 (0.54) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL8383162 | 0.81 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL6747735 | 0.81 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112625766-A | Gasoline additive and preparation method thereof | 泗县唯澳生物技术开发有限公司 | 2021-04-09 | — | — | CN | disclosed |
| US-9580434-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | ATTENUA, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160039833-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CATALYST BIOSCIENCES, INC. | 2016-02-11 | — | — | US | disclosed |
| US-20150080576-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT INC (US) | 2015-03-19 | — | — | US | disclosed |
| US-8921410-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-8859609-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130005789-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | TARGACEPT, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-20120289572-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | TARGACEPT, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-8268860-B2 | Sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| WO-2007027734-A2 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX, INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007027734-A2 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX, INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| EP-1720545-A1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | ChemoCentryx Inc (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20060074121-A1 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2006-04-06 | — | — | US | disclosed |
| US-20050234034-A1 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2005-10-20 | — | — | US | disclosed |
| WO-2005084667-A1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX, INC. (US) | 2005-09-15 | — | — | WO | disclosed |
| US-6107321-A | Diazabicyclooctane derivatives having selective 5-HT1Dalpha agonist activity | MERCK SHARP & DOHME LTD. (GB) | 2000-08-22 | — | — | US | disclosed |
| WO-1997011945-A1 | DIAZABICYCLOOCTANE DERIVATIVES HAVING SELECTIVE 5-HT1DALPHA ANTAGONIST ACTIVITY | MERCK SHARP & DOHME LIMITED (GB) | 1997-04-03 | — | — | WO | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289572-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | CHRNA2, CHRNE, CHRNA7 | ALDH1A1 2128/4885KMT2A 1653/4885MEN1 4492/4885 |
| US-20050234034-A1 | Bicyclic and bridged nitrogen heterocycles | CCR3, CCR1, CCR2 | ALDH1A1 2363/4885KMT2A 4608/4885MEN1 3847/4885 |
| US-20060074121-A1 | Bicyclic and bridged nitrogen heterocycles | CCR3, CCR1, CCR2 | ALDH1A1 2363/4885KMT2A 4608/4885MEN1 3847/4885 |
| US-20130005789-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | CHRNA2, CHRNE, CHRNA7 | ALDH1A1 2128/4885KMT2A 1653/4885MEN1 4492/4885 |
| US-20150080576-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA4, CHRNA2, CHRNE | ALDH1A1 1883/4885KMT2A 1813/4885MEN1 4644/4885 |
| US-20160039833-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA2, CHRNE, CHRNA7 | ALDH1A1 2128/4885KMT2A 1653/4885MEN1 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.