Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.52 |
| ▸ | DRD3 | P35462 | 7/20 | 0.52 |
| ▸ | HTR1A | P08908 | 5/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.52 |
| ▸ | HTR2B | P41595 | 5/20 | 0.52 |
| ▸ | DRD1 | P21728 | 4/20 | 0.52 |
| ▸ | DRD5 | P21918 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847154 | 0.91 | P2RX7 (0.59) | DRD2P2RX7CCR1SIGMAR1LMNA | |
| SCHEMBL8010420 | 0.80 | DRD2 (0.72) | DRD2DRD3HTR1ASLC6A2HTR2A | |
| SCHEMBL5846994 | 0.80 | DRD2 (0.52) | DRD2DRD3HTR1ASLC6A2HTR2A | |
| SCHEMBL5846289 | 0.76 | CCR1 (0.55) | DRD2DRD3HTR1ASLC6A2HTR2A | |
| SCHEMBL5847009 | 0.76 | DRD2 (0.52) | DRD2DRD3HTR1ASLC6A2HTR2A | |
| SCHEMBL5848265 | 0.75 | DRD2 (0.57) | DRD2DRD3HTR1ASLC6A2HTR2A | |
| SCHEMBL6346747 | 0.74 | P2RX7 (0.64) | P2RX7CYP1A2ADRA2A | |
| SCHEMBL5846198 | 0.73 | SIGMAR1 (0.55) | DRD2HTR1AHTR7P2RX7SIGMAR1 | |
| SCHEMBL8570792 | 0.73 | DRD2 (0.65) | DRD2DRD3HTR1ASLC6A2HTR2A | |
| SCHEMBL7665773 | 0.73 | DRD2 (0.65) | DRD2DRD3HTR1ASLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39113-E1 | Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-05-30 | — | — | US | claimed |
| EP-0721455-B9 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2005-04-20 | — | — | EP | claimed |
| EP-1097698-B1 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | ESTEVE LABOR DR (ES) | 2003-05-07 | — | — | EP | claimed |
| EP-0721455-B1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2002-12-11 | — | — | EP | claimed |
| EP-1097698-A2 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-05-09 | — | — | EP | claimed |
| CN-1166173-A | Tetrahydropyridine- (or 4-hydroxypiperidine) alkylpyrroles active at sigma and/or 5HTIA receptors | ESTEVE S A LAB DE DR (ES) | 1997-11-26 | — | — | CN | claimed |
| WO-1996004287-A1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1996-02-15 | — | — | WO | claimed |