SCHEMBL5847154

SCHEMBL5847154

OC1(c2ccccc2)CCN(CCCCn2ncc3ccccc32)CC1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.59
SIGMAR1 Q99720 1/20 0.55
KMO O15229 1/20 0.51
DRD2 P14416 2/20 0.51
CCR3 P51677 1/20 0.49
OPRL1 P41146 2/20 0.49
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
KMT2A Q03164 1/20 0.46
POLB P06746 1/20 0.46
SLC6A1 P30531 1/20 0.45
SLC6A12 P48065 1/20 0.45
SLC6A11 P48066 1/20 0.45
CCR1 P32246 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5848249 0.91 DRD2 (0.52) P2RX7SIGMAR1DRD2MEN1LMNA
SCHEMBL5847529 0.78 SIGMAR1 (0.58) P2RX7SIGMAR1DRD2CCR3OPRL1
SCHEMBL6346747 0.77 P2RX7 (0.64) P2RX7KMOPOLB
SCHEMBL11062805 0.76 SIGMAR1 (0.70) SIGMAR1DRD2CCR3OPRL1MEN1
Hydrochloric Acid SCHEMBL11073893 0.74 SIGMAR1 (0.68) SIGMAR1DRD2CCR3OPRL1MEN1
SCHEMBL9370237 0.74 SIGMAR1 (0.72) SIGMAR1DRD2CCR3OPRL1MEN1
SCHEMBL5846990 0.73 SIGMAR1 (0.59) SIGMAR1DRD2CCR3OPRL1MEN1
SCHEMBL5848148 0.73 CCR3 (0.58) SIGMAR1DRD2CCR3OPRL1POLB
SCHEMBL5847570 0.73 SIGMAR1 (0.55) SIGMAR1DRD2CCR3OPRL1MEN1
SCHEMBL5847565 0.73 DRD2 (0.59) P2RX7SIGMAR1DRD2CCR3OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39113-E1 Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain LABORATORIES DEL DR. ESTEVE, S.A. (ES) 2006-05-30 US claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
CN-1166173-A Tetrahydropyridine- (or 4-hydroxypiperidine) alkylpyrroles active at sigma and/or 5HTIA receptors ESTEVE S A LAB DE DR (ES) 1997-11-26 CN claimed
EP-1551832-A1 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LTD. (GB) 2005-07-13 EP disclosed
WO-2004031185-A1 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 2004-04-15 WO disclosed