Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.68 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30320686 | 1.00 | TOP2A (0.68) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL500719 | 0.90 | TOP2A (0.71) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL29463823 | 0.90 | TOP2A (0.71) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL14209463 | 0.89 | TOP2A (0.55) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10511131 | 0.88 | TOP2A (0.69) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| Potassium SCHEMBL10510827 | 0.88 | TOP2A (0.69) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10511115 | 0.88 | TOP2A (0.69) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10510815 | 0.88 | TOP2A (0.69) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL500386 | 0.86 | ALDH1A1 (0.66) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL8324772 | 0.86 | TOP2A (0.64) | TOP2ATOP2BALDH1A1POLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | claimed |
| CN-111514125-B | Composition containing quinolone compound and edetic acid compound | 中山万汉制药有限公司 | 2021-03-23 | — | — | CN | claimed |
| CN-111514125-A | Composition containing quinolone compound and edetic acid compound | 中山万汉制药有限公司 | 2020-08-11 | — | — | CN | claimed |
| CN-111150734-A | Compositions containing mixtures of quinolinone derivatives and uses thereof | 黄泳华 | 2020-05-15 | — | — | CN | claimed |
| WO-2006004561-A1 | PROCESS FOR THE PREPARATION OF GATIFLOXACIN AND REGENERATION OF DEGRADATION PRODUCTS | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2006-01-12 | — | — | WO | claimed |
| WO-2024104344-A1 | QUINOLINECARBOXYLIC ACID DERIVATIVE AND USE THEREOF | 沈阳中化农药化工研发有限公司 | 2024-05-23 | — | — | WO | disclosed |
| CN-118047721-A | Quinoline carboxylic acid derivative and application thereof | 沈阳中化农药化工研发有限公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | disclosed |
| CN-111514125-B | Composition containing quinolone compound and edetic acid compound | 中山万汉制药有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-111514125-A | Composition containing quinolone compound and edetic acid compound | 中山万汉制药有限公司 | 2020-08-11 | — | — | CN | disclosed |
| CN-111150734-A | Compositions containing mixtures of quinolinone derivatives and uses thereof | 黄泳华 | 2020-05-15 | — | — | CN | disclosed |
| EP-2102217-B1 | 4- (2-OXO-OXAZOLIDIN-3YL)-PHENOXYMETHYLE DERIVATIVEAS AS ANTIBACTERIALS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-02-15 | — | — | EP | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| EP-1931684-A2 | OXAZOLIDINONE-QUINOLONE HYBRIDS AS ANTIBACTERIAL COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2008-06-18 | — | — | EP | disclosed |
| WO-2008062379-A2 | 4- (2-OXO-OXAZOLIDIN-3YL)-PHENOXYMETHYLE DERIVATIVEAS AS ANTIBACTERIALS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-29 | — | — | WO | disclosed |
| US-20070219231-A1 | Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof | XINCHANG PHARMACEUTICAL FACTORY, ZHEJIANG MEDICINE CO. LTD. (CN) | 2007-09-20 | — | — | US | disclosed |
| EP-1767536-A1 | QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEREOF PREPARATION AND USAGE | Institute of Medicinal Biotechnology, Chinese Acadamy of Medical Sciences (CN) | 2007-03-28 | — | — | EP | disclosed |
| WO-2007017828-A2 | OXAZOLIDINONE-QUINOLONE HYBRIDS AS ANTIBACTERIAL COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-02-15 | — | — | WO | disclosed |
| WO-2006004561-A1 | PROCESS FOR THE PREPARATION OF GATIFLOXACIN AND REGENERATION OF DEGRADATION PRODUCTS | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219231-A1 | Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof | NQO2, ABCG2, DHX15 | TOP2A 256/4885TOP2B 471/4885ALDH1A1 1904/4885 |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | TOP2A 389/4885TOP2B 359/4885ALDH1A1 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.