Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31172812 | 0.82 | — | — | |
| SCHEMBL30798137 | 0.79 | CYP17A1 (0.46) | CYP17A1CYP19A1MEN1MAPK1KMT2A | |
| SCHEMBL5080907 | 0.76 | CYP17A1 (0.41) | CYP17A1CYP19A1MEN1MAPK1KMT2A | |
| SCHEMBL131064 | 0.76 | CYP17A1 (0.55) | CYP17A1CYP19A1MEN1MAPK1KMT2A | |
| SCHEMBL31172934 | 0.73 | — | — | |
| SCHEMBL136663 | 0.73 | NPSR1 (0.49) | CYP17A1CYP19A1MEN1MAPK1KMT2A | |
| SCHEMBL216423 | 0.73 | ALDH1A1 (0.43) | CYP17A1CYP19A1MEN1MAPK1KMT2A | |
| SCHEMBL14249653 | 0.71 | — | — | |
| SCHEMBL34474146 | 0.71 | DGAT1 (0.32) | MEN1MAPK1KMT2A | |
| SCHEMBL5451788 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580434-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | ATTENUA, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160039833-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CATALYST BIOSCIENCES, INC. | 2016-02-11 | — | — | US | disclosed |
| US-20150080576-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT INC (US) | 2015-03-19 | — | — | US | disclosed |
| US-8921410-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8859609-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130005789-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | TARGACEPT, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-20120289572-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | TARGACEPT, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-8268860-B2 | Sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| EP-2284171-B1 | Amides of diazabicycloalkanes selective for nicotinic acetylcholine receptor sub-types | TARGACEPT INC (US) | 2012-02-15 | — | — | EP | disclosed |
| US-8114889-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| EP-2094703-B1 | NICOTINIC ACETYLCHOLINE RECEPTORSUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT INC (US) | 2011-05-11 | — | — | EP | disclosed |
| US-20110071180-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| EP-2284171-A1 | Amides of diazabicycloalkanes selective for nicotinic acetylcholine receptor sub-types | Targacept, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| EP-2257549-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOAL KANES | Targacept Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| US-20100173932-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100081683-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGCEPT INC. (US) | 2010-04-01 | — | — | US | disclosed |
| WO-2009111550-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOAL KANES | TARGACEPT, INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| EP-2094703-A1 | NICOTINIC ACETYLCHOLINE RECEPTORSUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | Targacept, Inc. (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008057938-A1 | NICOTINIC ACETYLCHOLINE RECEPTORSUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289572-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | CHRNA2, CHRNE, CHRNA7 | CYP17A1 3635/4885CYP19A1 2270/4885MEN1 4492/4885 |
| US-20130005789-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | CHRNA2, CHRNE, CHRNA7 | CYP17A1 3635/4885CYP19A1 2270/4885MEN1 4492/4885 |
| US-20150080576-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA4, CHRNA2, CHRNE | CYP17A1 3786/4885CYP19A1 2445/4885MEN1 4644/4885 |
| US-20110071180-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA7, CHRNA2, CHRNA5 | CYP17A1 2172/4885CYP19A1 1345/4885MEN1 3632/4885 |
| US-20100081683-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA7, CHRNE, CHRNA2 | CYP17A1 3345/4885CYP19A1 1845/4885MEN1 3979/4885 |
| US-20100173932-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA4, CHRNA2, CHRNE | CYP17A1 3786/4885CYP19A1 2445/4885MEN1 4644/4885 |
| US-20160039833-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA2, CHRNE, CHRNA7 | CYP17A1 3635/4885CYP19A1 2270/4885MEN1 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.