Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CCKBR | P32239 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661426 | 0.88 | KDM4E (0.46) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL10759696 | 0.86 | ALOX5 (0.51) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL1161989 | 0.79 | ALOX5 (0.45) | ALOX5KDM4EHPGDALDH1A1GAA | |
| SCHEMBL27831047 | 0.79 | ALOX5 (0.50) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL518794 | 0.79 | ALOX5 (0.50) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL7647686 | 0.79 | CCKBR (0.39) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL11904769 | 0.78 | DRD2 (0.47) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL9316695 | 0.77 | GABBR2 (0.53) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL30508997 | 0.77 | ALOX5 (0.54) | ALOX5KDM4EMAPTDAOHPGD | |
| SCHEMBL8003423 | 0.77 | ALOX5 (0.54) | ALOX5KDM4EMAPTDAOHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-09-21 | — | — | US | disclosed |
| US-7084166-B2 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHEE RIUNITE S.P.A. (IT) | 2006-08-01 | — | — | US | disclosed |
| US-20040053987-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | ABCC1, MCL1, DPYD | ALOX5 1785/4885KDM4E 4063/4885MAPT 4619/4885 |
| US-20040053987-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | ABCC1, TOP1, CHEK1 | ALOX5 2065/4885KDM4E 3651/4885MAPT 4706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.