Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5852098 | 0.88 | MEN1 (0.44) | MAPK1MEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL5855012 | 0.82 | MAPK1 (0.41) | MAPK1MEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL5854750 | 0.81 | NPSR1 (0.39) | MAPK1MEN1ALDH1A1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5852985 | 0.80 | SOAT1 (0.43) | MEN1ALDH1A1KMT2ASMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL5853249 | 0.79 | SOAT1 (0.44) | MEN1ALDH1A1KMT2APOLBLMNA | |
| Hydrochloric Acid SCHEMBL5855548 | 0.79 | SOAT1 (0.44) | MEN1ALDH1A1KMT2APOLBLMNA | |
| Hydrochloric Acid SCHEMBL5853050 | 0.78 | ALOX5 (0.38) | MAPK1MEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL5853759 | 0.78 | MAPT (0.37) | MAPK1MEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL7108766 | 0.77 | ALDH1A1 (0.40) | MEN1ALDH1A1MAPTKMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5855900 | 0.76 | POLB (0.37) | MEN1ALDH1A1MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037989-B2 | Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2006-05-02 | — | — | US | disclosed |
| US-20040242814-A1 | COPOLYMERS OF ETHYLENE AND/OR ALPHA-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-12-02 | — | — | US | disclosed |