Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.49 |
| ▸ | LIG1 | P18858 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GPX4 | P36969 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5855850 | 1.00 | ALOX5 (0.49) | ALOX5LIG1HCAR2THRBALDH1A1 | |
| SCHEMBL5855118 | 0.95 | HCAR2 (0.56) | ALOX5LIG1HCAR2THRBALDH1A1 | |
| SCHEMBL5855108 | 0.95 | HCAR2 (0.56) | ALOX5LIG1HCAR2THRBALDH1A1 | |
| SCHEMBL7918625 | 0.82 | LIG1 (0.44) | ALOX5LIG1THRBALDH1A1KDM4E | |
| SCHEMBL28485379 | 0.78 | THRA (0.51) | LIG1THRBALDH1A1KDM4EHPGD | |
| SCHEMBL28241610 | 0.77 | THRB (0.54) | ALOX5THRBALDH1A1KDM4EHPGD | |
| SCHEMBL5854513 | 0.77 | ALDH1A1 (0.50) | LIG1ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL30365186 | 0.77 | LIG1 (0.49) | LIG1THRBALDH1A1KDM4EHPGD | |
| SCHEMBL24970941 | 0.76 | ALOX5 (0.52) | ALOX5THRBAKR1B10AKR1B1THRA | |
| SCHEMBL9819115 | 0.76 | THRB (0.55) | ALOX5HCAR2THRBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7038076-B2 | Fumarate derivative, method for producing the same | SHOWA DENKO K.K. (JP) | 2006-05-02 | — | — | US | disclosed |
| CN-1181040-C | Fumarate derivative and process for producing the same | 昭和电工株式会社 | 2004-12-22 | — | — | CN | disclosed |
| EP-1301461-A2 | FUMARATE DERIVATIVE, METHOD FOR PRODUCING THE SAME | Showa Denko K.K. (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-20030060563-A1 | Fumarate derivative, method for producing the same | SHOWA DENKO K.K. (JP) | 2003-03-27 | — | — | US | disclosed |
| CN-1386116-A | Fumarate derivative, method for producing the same | SHOWA DENKO KK (JP) | 2002-12-18 | — | — | CN | disclosed |
| WO-2002006206-A2 | FUMARATE DERIVATIVE, METHOD FOR PRODUCING THE SAME | SHOWA DENKO K.K. (JP) | 2002-01-24 | — | — | WO | disclosed |