Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 6/20 | 0.46 |
| ▸ | CTSG | P08311 | 6/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 6/20 | 0.46 |
| ▸ | CMA1 | P23946 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | PADI1 | Q9ULC6 | 5/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 5/20 | 0.43 |
| ▸ | PADI2 | Q9Y2J8 | 4/20 | 0.43 |
| ▸ | PADI3 | Q9ULW8 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5855307 | 1.00 | PRSS1 (0.46) | PRSS1CTSGCTRB1CMA1PPARG | |
| SCHEMBL5855621 | 1.00 | PRSS1 (0.46) | PRSS1CTSGCTRB1CMA1PPARG | |
| SCHEMBL5856010 | 0.92 | ITGB3 (0.47) | PRSS1CTSGCTRB1CMA1PPARG | |
| SCHEMBL5857630 | 0.92 | ITGB3 (0.47) | PRSS1CTSGCTRB1CMA1PPARG | |
| SCHEMBL5858377 | 0.92 | ITGB3 (0.47) | PRSS1CTSGCTRB1CMA1PPARG | |
| SCHEMBL5855731 | 0.91 | PRSS1 (0.47) | PRSS1CTSGCTRB1CMA1PADI1 | |
| SCHEMBL5857551 | 0.91 | PPARG (0.40) | PRSS1CTSGCTRB1CMA1PPARG | |
| SCHEMBL5855758 | 0.91 | PRSS1 (0.47) | PRSS1CTSGCTRB1CMA1PADI1 | |
| SCHEMBL5855147 | 0.91 | NR1H4 (0.41) | PRSS1CTSGCTRB1CMA1PPARG | |
| SCHEMBL5855987 | 0.91 | PRSS1 (0.47) | PRSS1CTSGCTRB1CMA1PADI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144906-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-12-05 | — | — | US | disclosed |
| US-7030143-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-18 | — | — | US | disclosed |
| US-7022723-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| EP-1634876-A2 | Heterocyclic compounds for the treatment of hyperlipidemia agents | Nippon Shinyaku Co., Ltd. (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6998412-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-02-14 | — | — | US | disclosed |
| US-20050009785-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20050009892-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20040162325-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2004-08-19 | — | — | US | disclosed |
| US-20030166697-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1295875-A1 | HETEROCYCLIC COMPOUNDS | Nippon Shinyaku Co., Ltd. (JP) | 2003-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009785-A1 | Heterocyclic compounds | LIPC, GPR119, APOB | PRSS1 943/4885CTSG 2668/4885CTRB1 209/4885 |
| US-20050009892-A1 | Heterocyclic compounds | GPR119, LIPC, LIPE | PRSS1 775/4885CTSG 2708/4885CTRB1 229/4885 |
| US-20040162325-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | PRSS1 781/4885CTSG 2984/4885CTRB1 266/4885 |
| US-20030166697-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | PRSS1 781/4885CTSG 2984/4885CTRB1 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.