Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.59 |
| ▸ | PPARA | Q07869 | 12/20 | 0.59 |
| ▸ | PPARD | Q03181 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5854753 | 0.98 | PPARG (0.57) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL6383881 | 0.94 | HRH3 (0.58) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL5855959 | 0.88 | PPARG (0.52) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL4389491 | 0.88 | HRH3 (0.61) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL5382866 | 0.87 | PPARG (0.58) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL5855804 | 0.87 | PPARG (0.53) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL5538021 | 0.85 | PPARG (0.59) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL5857599 | 0.85 | PPARG (0.62) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL27629630 | 0.85 | PPARG (0.58) | PPARGPPARAPPARDHRH3KDM4E | |
| SCHEMBL5544269 | 0.84 | PPARG (0.57) | PPARGPPARAPPARDHRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144906-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-12-05 | — | — | US | disclosed |
| US-7030143-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-18 | — | — | US | disclosed |
| US-7022723-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| EP-1634876-A2 | Heterocyclic compounds for the treatment of hyperlipidemia agents | Nippon Shinyaku Co., Ltd. (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6998412-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-02-14 | — | — | US | disclosed |
| US-20050009892-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20050009785-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20040162325-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2004-08-19 | — | — | US | disclosed |
| US-20030166697-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1295875-A1 | HETEROCYCLIC COMPOUNDS | Nippon Shinyaku Co., Ltd. (JP) | 2003-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009785-A1 | Heterocyclic compounds | LIPC, GPR119, APOB | PPARG 393/4885PPARA 464/4885PPARD 912/4885 |
| US-20050009892-A1 | Heterocyclic compounds | GPR119, LIPC, LIPE | PPARG 603/4885PPARA 579/4885PPARD 646/4885 |
| US-20040162325-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | PPARG 701/4885PPARA 660/4885PPARD 875/4885 |
| US-20030166697-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | PPARG 701/4885PPARA 660/4885PPARD 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.