Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475237 | 0.83 | KMT2A (0.44) | TSHRALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL6195517 | 0.80 | LMNA (0.35) | HPGDTSHRALDH1A1LMNAMEN1 | |
| SCHEMBL6695336 | 0.80 | ALDH1A1 (0.36) | KDM4ESMN1; SMN2HPGDTSHRALDH1A1 | |
| SCHEMBL6193631 | 0.78 | MEN1 (0.37) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6197177 | 0.77 | GAA (0.42) | KDM4EALDH1A1LMNAEPHX1 | |
| SCHEMBL5375422 | 0.76 | LMNA (0.45) | KDM4EHPGDLMNAMEN1KMT2A | |
| SCHEMBL5378919 | 0.76 | LMNA (0.45) | KDM4EHPGDLMNAMEN1KMT2A | |
| SCHEMBL9860372 | 0.75 | LMNA (0.53) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL5389844 | 0.75 | LMNA (0.46) | KDM4EHPGDRAB9ALMNACHRM1 | |
| SCHEMBL20818838 | 0.75 | KMT2A (0.50) | SMN1; SMN2TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270436-A1 | NOVEL AMINO- AND IMINO-ALKYLPIPERAZINES | RECORDATI IRELAND LIMITED (IE) | 2007-11-22 | — | — | US | disclosed |
| US-20060148821-A1 | N,N-disubstituted diazocycloalkanes | RECORDATI S.A. (CH) | 2006-07-06 | — | — | US | disclosed |
| US-7071197-B2 | N,N-disubstituted diazocycloalkanes | RECORDATI S.A. (CH) | 2006-07-04 | — | — | US | disclosed |
| EP-1515961-A1 | N,N-DISUBSTITUTED DIAZOCYCLOALKANES USEFUL FOR THE TREATMENT OF CNS DISORDERS DUE TO SEROTONERGIC DYSFUNCTION | Recordati Ireland Limited (IE) | 2005-03-23 | — | — | EP | disclosed |
| US-20040072822-A1 | N,N-disubstituted diazocycloalkanes | RECORDATI S.A. (CH) | 2004-04-15 | — | — | US | disclosed |
| WO-2003106444-A1 | N,N-DISUBSTITUTED DIAZOCYCLOALKANES USEFUL FOR THE TREATMENT OF CNS DISORDERS DUE TO SEROTONERGIC DYSFUNCTION | RECORDATI S.A. (CH) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072822-A1 | N,N-disubstituted diazocycloalkanes | HTR1D, HTR1A, HTR2C | KDM4E 4456/4885SMN1; SMN2 98/4885HPGD 2626/4885 |
| US-20070270436-A1 | NOVEL AMINO- AND IMINO-ALKYLPIPERAZINES | HTR5A, HTR1A, HTR2C | KDM4E 4003/4885SMN1; SMN2 101/4885HPGD 1430/4885 |
| US-20060148821-A1 | N,N-disubstituted diazocycloalkanes | HTR1A, HTR1D, HTR2C | KDM4E 4743/4885SMN1; SMN2 182/4885HPGD 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.