SCHEMBL5859657

SCHEMBL5859657

COc1ccccc1C(c1ccccc1)(c1ccccc1OC)C(O)[C@H]1O[C@@](C(=O)c2ccccc2)(n2cnc3c(N)ncnc32)C[C@@H]1O

nearest known ligand 0.34

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.34
ADORA1 P30542 2/20 0.34
SLC28A1 O00337 1/20 0.34
NNMT P40261 1/20 0.34
CHKA P35790 2/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
PI4KA P42356 2/20 0.33
PI4K2B Q8TCG2 2/20 0.33
PI4K2A Q9BTU6 2/20 0.33
PI4KB Q9UBF8 2/20 0.33
ADORA3 P0DMS8 1/20 0.32
ADORA2A P29274 1/20 0.32
AHCY P23526 1/20 0.32
GNMT Q14749 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5859677 0.83
SCHEMBL10430145 0.81 PDE4A (0.36) EGFRADORA1NNMTCHKAPDE4A
SCHEMBL4466122 0.78 EGFR (0.39) EGFRSLC28A1PDE4APDE4BPDE4C
SCHEMBL9015823 0.76 ADORA1 (0.44) ADORA1NNMTAHCY
SCHEMBL29812366 0.76 ADORA1 (0.44) EGFRADORA1SLC28A1ADORA3ADORA2A
SCHEMBL8652178 0.75 LMNA (0.34) CHKA
SCHEMBL7813909 0.75 EGFR (0.40) EGFRADORA1PDE4APDE4BPDE4C
SCHEMBL5580212 0.75 ADORA1 (0.55) ADORA1NNMTADORA3AHCY
SCHEMBL2952014 0.74 SLC28A1 (0.48) EGFRADORA1SLC28A1PI4KAPI4K2B
SCHEMBL29720399 0.73 ADORA1 (0.40) EGFRADORA1SLC28A1PI4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7135564-B1 Reusable solid support for oligonucleotide synthesis UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) 2006-11-14 US disclosed
EP-0877751-B1 LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF UNIV TECHNOLOGIES INT (CA) 2003-10-15 EP disclosed
US-20030129593-A1 Process for producing multiple oligonucleotides on a solid support UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. 2003-07-10 US disclosed
EP-1319012-A1 PROCESS FOR PRODUCING MULTIPLE OLIGONUCLEOTIDES ON A SOLID SUPPORT University Technologies International Inc. (CA) 2003-06-18 EP disclosed
EP-0876390-B1 REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS, PROCESS FOR PRODUCTION THEREOF AND PROCESS FOR USE THEREOF UNIV TECHNOLOGIES INT (CA) 2002-06-12 EP disclosed
WO-2002020541-A2 PROCESS FOR PRODUCING MULTIPLE OLIGONUCLEOTIDES ON A SOLID SUPPORT UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) 2002-03-14 WO disclosed
EP-0877751-A1 LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) 1998-11-18 EP disclosed
EP-0876390-A1 REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS, PROCESS FOR PRODUCTION THEREOF AND PROCESS FOR USE THEREOF UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) 1998-11-11 EP disclosed
WO-1997023496-A1 REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS, PROCESS FOR PRODUCTION THEREOF AND PROCESS FOR USE THEREOF UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) 1997-07-03 WO disclosed
WO-1997023497-A1 LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) 1997-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030129593-A1 Process for producing multiple oligonucleotides on a solid support RNGTT, IGF2BP1, IGF2BP2 EGFR 1185/4885ADORA1 4274/4885SLC28A1 3527/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.