SCHEMBL2952014

SCHEMBL2952014

Nc1ncnc2c1ncn2[C@@]1(C(=O)c2ccccc2)C[C@H](O)[C@@H](CO)O1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 2/20 0.48
ADORA3 P0DMS8 6/20 0.46
ADORA2A P29274 5/20 0.46
EGFR P00533 2/20 0.45
GMPS P49915 1/20 0.42
PI4KA P42356 3/20 0.41
PI4K2B Q8TCG2 3/20 0.41
PI4K2A Q9BTU6 3/20 0.41
PI4KB Q9UBF8 3/20 0.41
DPP4 P27487 1/20 0.41
MEN1 O00255 1/20 0.41
MAP3K7 O43318 1/20 0.41
SLC28A2 O43868 1/20 0.41
GAPDH P04406 1/20 0.41
MAPK1 P28482 1/20 0.41
ADORA2B P29275 1/20 0.41
ADORA1 P30542 1/20 0.41
STAT6 P42226 1/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL20702110 0.96 SLC28A1 (0.46) SLC28A1ADORA3ADORA2AEGFRGMPS
SCHEMBL29817041 0.91 SLC28A1 (0.45) SLC28A1ADORA3ADORA2AEGFRGMPS
SCHEMBL8714851 0.88 ADORA2A (0.44) SLC28A1ADORA3ADORA2AGMPSPI4KA
SCHEMBL27730982 0.87 SLC28A1 (0.49) SLC28A1ADORA3ADORA2AEGFRGMPS
SCHEMBL6513203 0.86 SLC28A1 (0.42) SLC28A1ADORA3ADORA2AGMPSPI4KA
SCHEMBL29812366 0.86 ADORA1 (0.44) SLC28A1ADORA3ADORA2AEGFRADORA1
SCHEMBL29720399 0.85 ADORA1 (0.40) SLC28A1ADORA3ADORA2AEGFRGMPS
SCHEMBL15875792 0.85 SLC28A1 (0.53) SLC28A1ADORA3ADORA2AEGFRGMPS
SCHEMBL8576963 0.84 ADORA2A (0.41) SLC28A1ADORA3ADORA2AEGFRGMPS
SCHEMBL8058704 0.84 SLC28A1 (0.52) SLC28A1ADORA3ADORA2AEGFRGMPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0754242-A4 OLIGONUCLEOTIDE N3'-m(7)P5' PHOSPHORAMIDATES: SYNTHESIS AND COMPOUNDS; HYBRIDIZATION AND NUCLEASE RESISTANCE PROPERTIES LYNX THERAPEUTICS INC (US) 1997-06-11 EP claimed
EP-0754242-A1 OLIGONUCLEOTIDE N3'$m(7)P5' PHOSPHORAMIDATES: SYNTHESIS AND COMPOUNDS; HYBRIDIZATION AND NUCLEASE RESISTANCE PROPERTIES LYNX THERAPEUTICS, INC. (US) 1997-01-22 EP claimed
WO-1995025814-A1 OLIGONUCLEOTIDE N3'→P5' PHOSPHORAMIDATES: SYNTHESIS AND COMPOUNDS; HYBRIDIZATION AND NUCLEASE RESISTANCE PROPERTIES LYNX THERAPEUTICS, INC. (US) 1995-09-28 WO claimed
EP-0548189-A1 A METHOD OF LINKING NUCLEOSIDES WITH A SILOXANE BRIDGE. STERLING WINTHROP INC (US) 1993-06-30 EP claimed
WO-1992004364-A1 A METHOD OF LINKING NUCLEOSIDES WITH A SILOXANE BRIDGE STERLING WINTHROP INC. (US) 1992-03-19 WO claimed
US-12559517-B2 Oligonucleotide manufacturing method AJINOMOTO CO., INC. (JP) 2026-02-24 US disclosed
US-20260028368-A1 OLIGONUCLEOTIDE SYNTHESIS ON SOLID SUPPORT INTEGRATED DNA TECH INC (US) 2026-01-29 US disclosed
US-12459968-B2 Oligonucleotide synthesis on solid support INTEGRATED DNA TECHNOLOGIES, INC. (US) 2025-11-04 US disclosed
EP-4413130-A1 NUCLEIC ACIDS CONTAINING ABASIC NUCLEOSIDES E-Therapeutics plc (GB) 2024-08-14 EP disclosed
US-12006540-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-06-11 US disclosed
US-11999999-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-06-04 US disclosed
US-11959137-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-04-16 US disclosed
EP-0754242-A1 OLIGONUCLEOTIDE N3'$m(7)P5' PHOSPHORAMIDATES: SYNTHESIS AND COMPOUNDS; HYBRIDIZATION AND NUCLEASE RESISTANCE PROPERTIES LYNX THERAPEUTICS, INC. (US) 1997-01-22 EP disclosed
WO-1995031470-A2 ANTISENSE INHIBITORS OF GENE EXPRESSION MERCK FROSST CANADA INC. (CA) 1995-11-23 WO disclosed
WO-1995025814-A1 OLIGONUCLEOTIDE N3'→P5' PHOSPHORAMIDATES: SYNTHESIS AND COMPOUNDS; HYBRIDIZATION AND NUCLEASE RESISTANCE PROPERTIES LYNX THERAPEUTICS, INC. (US) 1995-09-28 WO disclosed
EP-0570514-A4 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES INC (US) 1994-08-17 EP disclosed
EP-0570514-A1 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES, INC. (US) 1993-11-24 EP disclosed
WO-1992013869-A1 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES, INC. (US) 1992-08-20 WO disclosed
EP-0202758-A1 Hybridization method and probes therefor ZENECA LIMITED (GB) 1986-11-26 EP disclosed
EP-0058954-A2 Tridecadeoxynucleotide, process for its preparation and the application Dr. Karl Thomae GmbH (DE) 1982-09-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11959137-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis POLRMT, RNGTT, MTR SLC28A1 931/4885ADORA3 3497/4885ADORA2A 2915/4885
US-20260028368-A1 OLIGONUCLEOTIDE SYNTHESIS ON SOLID SUPPORT NSUN2, RNGTT, POLR2H SLC28A1 671/4885ADORA3 1594/4885ADORA2A 2177/4885
US-11999999-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis POLRMT, RNGTT, MTR SLC28A1 931/4885ADORA3 3497/4885ADORA2A 2915/4885
US-12006540-B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis POLRMT, RNGTT, MTR SLC28A1 931/4885ADORA3 3497/4885ADORA2A 2915/4885
US-12459968-B2 Oligonucleotide synthesis on solid support RNGTT, SSU72, NSUN2 SLC28A1 400/4885ADORA3 1988/4885ADORA2A 1656/4885
US-12559517-B2 Oligonucleotide manufacturing method POLL, IGF2BP1, POLI SLC28A1 631/4885ADORA3 2462/4885ADORA2A 1916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.