Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859281 | 0.90 | CYP3A4 (0.48) | BRAFKMT2APOLBLMNAPKM | |
| SCHEMBL5859923 | 0.90 | MAPT (0.49) | BRAFKMT2AABL1BCRLMNA | |
| SCHEMBL5859855 | 0.89 | NPC1 (0.51) | KMT2APOLBLMNARAB9ANPC1 | |
| SCHEMBL5862046 | 0.89 | NPC1 (0.50) | KMT2APOLBLMNAKDM4ERAB9A | |
| SCHEMBL5859069 | 0.87 | NPC1 (0.46) | KMT2APOLBLMNAKDM4ERAB9A | |
| SCHEMBL5859192 | 0.85 | PSMD14 (0.51) | BRAFPSMD14IRAK4KMT2APOLB | |
| SCHEMBL5862147 | 0.83 | KDM4E (0.42) | LMNAKDM4E | |
| SCHEMBL5859082 | 0.81 | MEN1 (0.48) | KMT2APOLBLMNARAB9ANPC1 | |
| SCHEMBL5860337 | 0.80 | APOB (0.44) | BRAF | |
| SCHEMBL5859235 | 0.77 | CYP2C9 (0.45) | KMT2AABL1BCRTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122543-B2 | Substituted benzoic acid derivatives having NF-κB inhibiting action | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2006-10-17 | — | — | US | disclosed |
| EP-1437339-A1 | SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING NF-KAPPA B INHIBITING ACTIVITY | Daiichi Suntory Pharma Co., Ltd. (JP) | 2004-07-14 | — | — | EP | disclosed |