Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 10/20 | 0.44 |
| ▸ | MTTP | P55157 | 10/20 | 0.44 |
| ▸ | SMO | Q99835 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859923 | 0.91 | MAPT (0.49) | TRPV1BRAF | |
| SCHEMBL5859281 | 0.90 | CYP3A4 (0.48) | JAK2TYK2BRAF | |
| SCHEMBL5860306 | 0.86 | SMO (0.44) | APOBMTTPSMOJAK2JAK1 | |
| SCHEMBL5862046 | 0.83 | NPC1 (0.50) | — | |
| SCHEMBL5859855 | 0.81 | NPC1 (0.51) | — | |
| SCHEMBL5859860 | 0.80 | IKBKB (0.37) | — | |
| SCHEMBL5860145 | 0.80 | BRAF (0.49) | BRAF | |
| SCHEMBL5859140 | 0.79 | CNR1 (0.45) | TYK2 | |
| SCHEMBL5859286 | 0.79 | TAS1R3 (0.38) | — | |
| SCHEMBL6661408 | 0.78 | GPR27 (0.44) | APOBMTTPSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122543-B2 | Substituted benzoic acid derivatives having NF-κB inhibiting action | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2006-10-17 | — | — | US | disclosed |
| EP-1437339-A1 | SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING NF-KAPPA B INHIBITING ACTIVITY | Daiichi Suntory Pharma Co., Ltd. (JP) | 2004-07-14 | — | — | EP | disclosed |