Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811455 | 0.78 | PPARA (0.71) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL6811644 | 0.77 | PPARA (0.52) | SMN1; SMN2MAPTL3MBTL1ALDH1A1PPARA | |
| SCHEMBL28357093 | 0.76 | POLB (0.59) | MAPTALDH1A1PPARANPSR1PPARG | |
| SCHEMBL11099701 | 0.75 | KMT2A (0.63) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL1269735 | 0.75 | ERCC5 (0.64) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL11490486 | 0.75 | SRD5A2 (0.50) | GAAHTTPPARALMNASRD5A2 | |
| SCHEMBL3485914 | 0.74 | SLC6A4 (0.41) | SRD5A2 | |
| SCHEMBL10883891 | 0.74 | HDAC3 (0.60) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL8057944 | 0.73 | PPARA (0.45) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL4730249 | 0.73 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844047-B2 | Process for the preparation of bazedoxifene | ERREGIERRE S.P.A. (IT) | 2020-11-24 | — | — | US | disclosed |
| EP-2118058-B9 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | ZENTIVA KS (CZ) | 2012-03-28 | — | — | EP | disclosed |
| EP-2118058-B1 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | ZENTIVA KS (CZ) | 2011-06-08 | — | — | EP | disclosed |
| US-20100087661-A1 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | ZENTIVA K.S. (CZ) | 2010-04-08 | — | — | US | disclosed |
| EP-2118058-A1 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | Zentiva, k.s. (CZ) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098527-A1 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | ZENTIVA A.S. (CZ) | 2008-08-21 | — | — | WO | disclosed |
| US-5710168-A | 2-piperidino-1-alkanol derivatives as neuroprotective agents | PFIZER INC. (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0398578-B1 | 2-piperidino-1-alkanol derivatives as antiischemic agents | PFIZER (US) | 1997-03-12 | — | — | EP | disclosed |
| CN-1032209-C | 2-piperidino-1-alkanol derivatives as antiischemic agents | PFIZER (US) | 1996-07-03 | — | — | CN | disclosed |
| US-5527912-A | USEFUL INTREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1996-06-18 | — | — | US | disclosed |
| US-5338754-A | 2-pyrrolidino-1-alkanol derivatives as antiischemic agents | PFIZER INC (US) | 1994-08-16 | — | — | US | disclosed |
| US-5272160-A | 2-piperidino-1-alkanol derivatives as antiischemic agents | PFIZER INC (US) | 1993-12-21 | — | — | US | disclosed |
| US-5185343-A | NORTROPYL-1-ALKANOL DERIVATIVES AS ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1993-02-09 | — | — | US | disclosed |
| WO-1990014087-A1 | 2-PIPERIDINO-1-ALKANOL DERIVATIVES AS ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1990-11-29 | — | — | WO | disclosed |
| WO-1990014088-A1 | 2-PIPERIDINO-1-ALKANOL DERIVATIVES AS ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1990-11-29 | — | — | WO | disclosed |
| CN-1047291-A | The 2-of anti-ischaemic agent croak pyridine subbase-1-alkanol derivatives | PFIZER (US) | 1990-11-28 | — | — | CN | disclosed |
| EP-0398578-A2 | 2-piperidino-1-alkanol derivatives as antiischemic agents | PFIZER INC. (US) | 1990-11-22 | — | — | EP | disclosed |
| US-4528194-A | 2-(4-Diphenylmethylpiperazinyl)-1-phenyl alkanol or their salts, a process for their production and a cerebral circulation-improving drug | NIPPON CHEMIPHAR CO., LTD. (JP) | 1985-07-09 | — | — | US | disclosed |
| US-4233307-A | Spiro-4'-piperidine compounds and their pharmaceutical compositions | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-11-11 | — | — | US | disclosed |
| US-3966814-A | PERIPHERAL VASODILATORS, ANTIHISTAMINES, SPASMOLYTICS | BOEHRINGER INGELHEIM GMBH (DT) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087661-A1 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | CYP19A1, CYP17A1, SHBG | SMN1; SMN2 3052/4885MAPT 4498/4885L3MBTL1 4564/4885 |
| US-10844047-B2 | Process for the preparation of bazedoxifene | CYP19A1, CYP3A5, CYP4A11 | SMN1; SMN2 4104/4885MAPT 3158/4885L3MBTL1 4804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.