Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744052 | 0.81 | EGFR (0.53) | PKMGAAALDH1A1RXFP1MAPT | |
| SCHEMBL6744833 | 0.80 | POLB (0.48) | PKMGAAALDH1A1RXFP1TP53 | |
| SCHEMBL5860975 | 0.79 | KMT2A (0.53) | PKMGAARAPGEF4ALDH1A1RXFP1 | |
| SCHEMBL5861275 | 0.78 | HPGD (0.41) | GAAKMT2AHTTHPGD | |
| SCHEMBL14485916 | 0.76 | PKM (0.58) | PKMGAARAPGEF4ALDH1A1CYP3A4 | |
| SCHEMBL14485941 | 0.74 | PKM (0.50) | PKMGAARAPGEF4ALDH1A1CYP3A4 | |
| SCHEMBL5862275 | 0.72 | RAPGEF4 (0.56) | RAPGEF4 | |
| SCHEMBL8145743 | 0.72 | PKM (0.62) | PKMGAARAPGEF4RXFP1MAPT | |
| SCHEMBL13074716 | 0.72 | PKM (1.00) | PKMGAARAPGEF4ALDH1A1POLB | |
| SCHEMBL14486413 | 0.72 | PKM (1.00) | PKMGAARAPGEF4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030145-B2 | Pyridinyl derivatives for the treatment of depression | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| US-20040209917-A1 | Pyridinyl derivatives for the treatment of depression | HARTZ RICHARD A (US) | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209917-A1 | Pyridinyl derivatives for the treatment of depression | CRH, CRHR1, CRHR2 | PKM 796/4885GAA 4203/4885RAPGEF4 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.