Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864059 | 0.84 | PSMB1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5864101 | 0.84 | PSEN1 (0.46) | HTR1AHTR7PSEN1PSEN2APH1B | |
| SCHEMBL5863662 | 0.74 | LTA4H (0.45) | HTR1AHTR7HRH3MEN1LTA4H | |
| SCHEMBL5863480 | 0.73 | LTA4H (0.40) | HRH3PSMB1PSMB5LTA4HKCNH2 | |
| SCHEMBL5863669 | 0.72 | PSMB1 (0.49) | HRH3PSMB1PSMB5AXLALDH1A1 | |
| SCHEMBL5863672 | 0.72 | HRH3 (0.37) | HRH3LTA4HKCNH2PTGS2 | |
| SCHEMBL6151300 | 0.71 | LTA4H (0.43) | HRH3AXLMERTKLTA4HKCNH2 | |
| SCHEMBL5863622 | 0.71 | MMP1 (0.51) | HRH3ALDH1A1LTA4HKCNH2 | |
| SCHEMBL5863837 | 0.71 | LTA4H (0.38) | HRH3PSMB1PSMB5MEN1KMT2A | |
| SCHEMBL5864090 | 0.70 | MMP1 (0.42) | HRH3PSMB1PSMB5LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | HTR1A 1005/4885HTR7 2347/4885PSEN1 1564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.