Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863370 | 0.78 | LTA4H (0.61) | LTA4HHRH3KCNH2 | |
| SCHEMBL5863662 | 0.73 | LTA4H (0.45) | LTA4HHRH3KCNH2 | |
| SCHEMBL5864067 | 0.71 | HTR1A (0.41) | LTA4HHRH3KCNH2AXLMERTK | |
| SCHEMBL5863673 | 0.70 | LTA4H (0.59) | LTA4HHRH3KCNH2 | |
| SCHEMBL5864259 | 0.70 | MCHR1 (0.55) | LTA4HHRH3 | |
| SCHEMBL5863641 | 0.69 | LTA4H (0.54) | LTA4HHRH3KCNH2 | |
| SCHEMBL17845123 | 0.69 | ESR1 (0.46) | LTA4HHRH3KCNH2ESR1 | |
| SCHEMBL5863874 | 0.69 | MMP1 (0.44) | LTA4HHRH3KCNH2ESR1ESR2 | |
| SCHEMBL5863622 | 0.69 | MMP1 (0.51) | LTA4HHRH3KCNH2 | |
| SCHEMBL7800033 | 0.68 | OXTR (0.43) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542967-A1 | AMIDE AND SULFONAMIDE LIGANDS FOR THE ESTROGEN RECEPTOR | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004026823-A1 | AMIDE AND SULFONAMIDE LIGANDS FOR THE ESTROGEN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |