Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 9/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863774 | 1.00 | SPHK1 (0.41) | SPHK1SPHK2KEAP1PARP1 | |
| SCHEMBL5863748 | 0.90 | HRH3 (0.42) | — | |
| SCHEMBL5863747 | 0.90 | OPRK1 (0.39) | SPHK1SPHK2KEAP1 | |
| SCHEMBL5863924 | 0.88 | HRH3 (0.40) | — | |
| SCHEMBL5864104 | 0.85 | OPRM1 (0.41) | KEAP1 | |
| SCHEMBL5863804 | 0.84 | HRH1 (0.41) | KEAP1 | |
| SCHEMBL5863535 | 0.83 | OPRM1 (0.42) | KEAP1 | |
| SCHEMBL5863814 | 0.83 | SIGMAR1 (0.41) | — | |
| SCHEMBL5863342 | 0.81 | KEAP1 (0.41) | KEAP1 | |
| SCHEMBL5863878 | 0.81 | OPRM1 (0.39) | KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | SPHK1 315/4885SPHK2 292/4885KEAP1 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.