Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506734 | 0.93 | PLA2G2A (0.50) | TSPOPLA2G2AMTNR1AMTNR1BHCRTR1 | |
| SCHEMBL5864649 | 0.89 | PLA2G2A (0.43) | TSPOPLA2G2AFABP4HTR6FABP3 | |
| SCHEMBL6690535 | 0.89 | TSPO (0.57) | TSPOPLA2G2AMTNR1AMTNR1BFABP4 | |
| SCHEMBL5864637 | 0.86 | FABP4 (0.43) | TSPOPLA2G2AMTNR1AMTNR1BFABP4 | |
| SCHEMBL5508890 | 0.82 | PLA2G2A (0.55) | TSPOPLA2G2AMTNR1AMTNR1BHCRTR1 | |
| SCHEMBL5864516 | 0.81 | PLA2G2A (0.57) | TSPOPLA2G2A | |
| SCHEMBL17286656 | 0.79 | PLA2G2A (0.40) | PLA2G2AMTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL5864560 | 0.78 | PLA2G2A (0.57) | PLA2G2A | |
| SCHEMBL14598609 | 0.77 | PLA2G2A (0.47) | TSPOPLA2G2AMTNR1AMTNR1BHCRTR1 | |
| SCHEMBL27505510 | 0.77 | HTR6 (0.50) | TSPOFABP4HCRTR1HCRTR2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109231-B2 | Cyclohept[b]indole derivatives | ELI LILLY AND COMPANY (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1438290-B1 | CYCLOHEPT B!INDOLE DERIVATIVES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040198801-A1 | Cyclohept'b!indole derivatives as spla2 inhibitors | KINNICK MICHAEL DEAN (US) | 2004-10-07 | — | — | US | disclosed |
| EP-1438290-A1 | CYCLOHEPT B!INDOLE DERIVATIVES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003016277-A1 | CYCLOHEPT`B!INDOLE DERIVATIVES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198801-A1 | Cyclohept'b!indole derivatives as spla2 inhibitors | SPTSSB, CPT1A, TPH2 | TSPO 1726/4885PLA2G2A 82/4885MTNR1A 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.