Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 1.00 |
| ▸ | RAB9A | P51151 | 14/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 1.00 |
| ▸ | TP53 | P04637 | 9/20 | 1.00 |
| ▸ | PKM | P14618 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.78 |
| ▸ | TSHR | P16473 | 5/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | ATM | Q13315 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15798260 | 0.90 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL7567703 | 0.89 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL29013034 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL30398266 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL13779310 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL3618549 | 0.88 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL2610072 | 0.88 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL19828201 | 0.85 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL31613770 | 0.84 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL19746324 | 0.84 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024240748-A1 | IMPROVED METHOD FOR THE FORMATION OF AMIDES | BASF SE (DE) | 2024-11-28 | — | — | WO | disclosed |
| CN-109475521-B | Anti-proprotein convertase subtilisin Kexin type 9 (anti-PCSK 9) compounds and methods of use thereof for treating and/or preventing cardiovascular diseases | 实发生物医学公司 | 2022-11-15 | — | — | CN | disclosed |
| US-10947220-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | SHIFA BIOMEDICAL CORPORATION (US) | 2021-03-16 | — | — | US | disclosed |
| US-10899748-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | SHIFA BIOMEDICAL CORPORATION (US) | 2021-01-26 | — | — | US | disclosed |
| US-20200262822-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | SHIFA BIOMEDICAL CORPORATION | 2020-08-20 | — | — | US | disclosed |
| US-20190270729-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-09-05 | — | — | US | disclosed |
| EP-3471714-A1 | ANTI-PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (ANTI-PCSK9) COMPOUNDS AND METHODS OF USING THE SAME IN THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | Shifa Biomedical Corporation (US) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017222953-A1 | ANTI-PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (ANTI-PCSK9) COMPOUNDS AND METHODS OF USING THE SAME IN THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | SHIFA BIOMEDICAL CORPORATION (US) | 2017-12-28 | — | — | WO | disclosed |
| US-7148259-B1 | Antibacterial agents | AMGEN INC. (US) | 2006-12-12 | — | — | US | disclosed |
| US-20060270651-A1 | ANTIBACTERIAL AGENTS | AMGEN INC. (US) | 2006-11-30 | — | — | US | disclosed |
| US-7053234-B2 | Antibacterial agents | AMGEN INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040235911-A1 | hydroxyamidines; antibiotic resistance | TULARIK INC. | 2004-11-25 | — | — | US | disclosed |
| US-6780858-B2 | Antibacterial agents | TULARIK INC. | 2004-08-24 | — | — | US | disclosed |
| EP-1246795-A2 | ANTIBACTERIAL AGENTS | Tularik Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
| US-20020045749-A1 | Antibacterial agents | AMGEN INC. | 2002-04-18 | — | — | US | disclosed |
| WO-2001051456-A2 | ANTIBACTERIAL AGENTS | TULARIK INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| US-5254592-A | Multiply substituted anilines, phenols and pyridines-immunomodulating agents | STERLING DRUG INC. (US) | 1993-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10899748-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | PCSK9, PCSK6, PCSK7 | NPC1 120/4885RAB9A 1970/4885SMN1; SMN2 4671/4885 |
| US-20040235911-A1 | hydroxyamidines; antibiotic resistance | HNMT, HDHD5, ABCC1 | NPC1 2881/4885RAB9A 941/4885SMN1; SMN2 2862/4885 |
| US-20200262822-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | PCSK9, PCSK6, PCSK7 | NPC1 120/4885RAB9A 1970/4885SMN1; SMN2 4671/4885 |
| US-20060270651-A1 | ANTIBACTERIAL AGENTS | MRPL21, HDHD5, CLPP | NPC1 2994/4885RAB9A 1357/4885SMN1; SMN2 3304/4885 |
| US-20020045749-A1 | Antibacterial agents | MRPL21, HDHD5, CLPP | NPC1 2994/4885RAB9A 1357/4885SMN1; SMN2 3304/4885 |
| US-20190270729-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | PCSK9, PCSK6, PCSK7 | NPC1 120/4885RAB9A 1970/4885SMN1; SMN2 4671/4885 |
| US-10947220-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | PCSK9, PCSK6, PCSK7 | NPC1 120/4885RAB9A 1970/4885SMN1; SMN2 4671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.