Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 20/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414064 | 0.97 | PLA2G7 (1.00) | PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL5867475 | 0.96 | PLA2G7 (0.99) | PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9 | |
| Fumaric Acid SCHEMBL5867372 | 0.93 | PLA2G7 (0.92) | PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9 | |
| Cadaverine Tartrate SCHEMBL5867362 | 0.93 | PLA2G7 (0.92) | PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL4417165 | 0.93 | PLA2G7 (1.00) | PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL4415584 | 0.91 | PLA2G7 (0.88) | PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL4416238 | 0.91 | PLA2G7 (1.00) | PLA2G7CYP3A4 | |
| SCHEMBL4419834 | 0.91 | PLA2G7 (1.00) | PLA2G7CYP3A4 | |
| Hydrochloric Acid SCHEMBL4412744 | 0.90 | PLA2G7 (0.87) | PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL4411693 | 0.90 | PLA2G7 (1.00) | PLA2G7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| EP-1479671-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2004-11-24 | — | — | EP | disclosed |
| US-20040167142-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM P.L.C. | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167142-A1 | Pyrimidinone compounds | LPL, LIPG, PCSK9 | PLA2G7 43/4885CYP3A4 1555/4885CYP2D6 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.