Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726650 | 0.79 | TP53 (0.48) | L3MBTL1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL25185325 | 0.72 | ADRA1D (0.45) | L3MBTL1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL24769737 | 0.68 | ADRA1D (0.51) | L3MBTL1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL9592410 | 0.67 | L3MBTL1 (1.00) | L3MBTL1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1286422 | 0.67 | — | — | |
| SCHEMBL692444 | 0.66 | L3MBTL1 (0.58) | L3MBTL1KDM4EMEN1KMT2AGAA | |
| SCHEMBL27819223 | 0.66 | CHRNB2 (0.44) | L3MBTL1KDM4ELMNAGAAALDH1A1 | |
| SCHEMBL10973292 | 0.66 | L3MBTL1 (0.58) | L3MBTL1KDM4EMEN1KMT2AGAA | |
| SCHEMBL11084732 | 0.66 | L3MBTL1 (0.58) | L3MBTL1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL1408606 | 0.65 | ALDH1A1 (0.41) | L3MBTL1MEN1KMT2ALMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138404-B2 | 4-aminopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-21 | — | — | US | disclosed |