Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256609 | 1.00 | LMNA (0.43) | LMNATP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8249703 | 0.81 | RAB9A (0.45) | TP53MAPTSMN1; SMN2PPARAKDM4E | |
| SCHEMBL5870149 | 0.81 | RAB9A (0.45) | TP53MAPTSMN1; SMN2PPARAKDM4E | |
| SCHEMBL7426729 | 0.77 | TP53 (0.39) | LMNATP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1655299 | 0.76 | ATM (0.46) | LMNATP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7425245 | 0.75 | HSD17B10 (0.39) | LMNATP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7417878 | 0.73 | RAB9A (0.46) | LMNATP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7419304 | 0.73 | SMN1; SMN2 (0.47) | LMNATP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5870039 | 0.73 | DRD2 (0.42) | — | |
| SCHEMBL5869659 | 0.72 | ALDH1A1 (0.46) | LMNATP53MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |