Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NLN | Q9BYT8 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8255793 | 1.00 | POLB (0.52) | POLBNLNKMT2A | |
| SCHEMBL5870452 | 0.90 | REN (0.53) | NLN | |
| SCHEMBL8249066 | 0.90 | REN (0.53) | NLN | |
| SCHEMBL8255250 | 0.79 | ITGB2 (0.54) | KMT2A | |
| SCHEMBL5870092 | 0.78 | TAAR1 (0.47) | POLB | |
| SCHEMBL9830947 | 0.73 | MME (0.57) | POLB | |
| SCHEMBL9830757 | 0.72 | CA2 (0.67) | POLB | |
| SCHEMBL16673388 | 0.71 | ITGB2 (0.49) | POLB | |
| SCHEMBL21794926 | 0.69 | NLN (0.68) | NLN | |
| SCHEMBL1667212 | 0.69 | ALDH1A1 (0.54) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |