Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090597 | 0.78 | NPC1 (0.35) | NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7543136 | 0.75 | MEN1 (0.36) | NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27628961 | 0.74 | CYP2C19 (0.40) | ALDH1A1CYP2C19 | |
| SCHEMBL7448545 | 0.73 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL7542970 | 0.73 | CAPN1 (0.36) | ALDH1A1 | |
| SCHEMBL7371580 | 0.73 | MEN1 (0.34) | NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6627459 | 0.72 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL27733749 | 0.71 | ALDH1A1 (0.38) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL9181315 | 0.70 | PREP (0.38) | NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7371962 | 0.70 | DRD4 (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141412-B2 | Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation | EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) | 2006-11-28 | — | — | US | disclosed |
| US-20030219883-A1 | Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation | LI ZHI (CH) | 2003-11-27 | — | — | US | disclosed |
| EP-1131460-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE 3-HYDROXY-PYRROLIDINE DERIVATIVEES BY ENZYMATIC HYDROXYLATION | Eidgenössische Technische Hochschule Zürich (CH) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029606-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE-3-HYDROXY-PYRROLIDINE DERIVATIVES BY ENZYMATIC HYDROXYLATION | Eidgenössische Technische Hochschule Zürich (CH) | 2000-05-25 | — | — | WO | disclosed |