Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371580 | 0.90 | MEN1 (0.34) | MEN1KMT2ANPSR1ALDH1A1PREP | |
| SCHEMBL7371962 | 0.85 | DRD4 (0.34) | MEN1KMT2ANPSR1ALDH1A1TACR1 | |
| SCHEMBL7375487 | 0.82 | SLC18A3 (0.41) | MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL7542970 | 0.81 | CAPN1 (0.36) | MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL5871291 | 0.75 | NPC1 (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27628961 | 0.69 | CYP2C19 (0.40) | ALDH1A1 | |
| SCHEMBL30819028 | 0.68 | TACR1 (0.58) | MEN1KMT2ATACR1 | |
| SCHEMBL7415044 | 0.68 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27733749 | 0.67 | ALDH1A1 (0.38) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9180507 | 0.66 | FABP7 (0.40) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194152-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1194152-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001000214-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |