Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312803 | 0.87 | MMP8 (0.62) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL5872172 | 0.86 | MMP8 (0.41) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL5871840 | 0.84 | PTPRB (0.54) | MMP8ALDH1A1LDHAPTPRB | |
| SCHEMBL5871668 | 0.83 | TSHR (0.42) | MMP8ALDH1A1TP53TDP1MEN1 | |
| SCHEMBL29038252 | 0.83 | MMP8 (0.41) | MMP8PKMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8895434 | 0.83 | MMP8 (0.41) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL5871820 | 0.82 | TSHR (0.44) | MMP8ALDH1A1TP53TDP1TSHR | |
| SCHEMBL165382 | 0.81 | MMP8 (0.76) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL6711568 | 0.81 | MMP8 (0.57) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL5871978 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TP53TSHRSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1266151-C | Naphthyridine derivatives | OTSUKA PHARMA CO LTD (JP) | 2006-07-26 | — | — | CN | disclosed |
| US-7071187-B2 | Naphthyridine derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2006-07-04 | — | — | US | disclosed |
| CN-1547581-A | Naphthyridine derivatives | 株式会社大V制药工场 | 2004-11-17 | — | — | CN | disclosed |
| US-20040214853-A1 | Naphthyridine derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2004-10-28 | — | — | US | disclosed |
| EP-1426374-A1 | NAPHTHYRIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2004-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214853-A1 | Naphthyridine derivatives | MT-ND1, OPRD1, NR0B1 | MMP8 4083/4885ALDH1A1 272/4885TP53 4064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.