SCHEMBL5872356

SCHEMBL5872356

Fc1c(F)c(F)c2c(c1F)-c1c(F)c(F)c(F)c(F)c1C2c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.34
CES2 O00748 1/20 0.33
ADRB1 P08588 1/20 0.32
IKBKB O14920 1/20 0.31
ITGB3 P05106 1/20 0.31
ITGAV P06756 1/20 0.31
KDM1A O60341 1/20 0.30
RPS6KA3 P51812 1/20 0.30
JAK3 P52333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5872317 0.72 PNMT (0.38) IDO1CES2KDM1A
SCHEMBL17555046 0.72 IKBKB (0.43) IDO1CES2ADRB1IKBKB
SCHEMBL24254714 0.68 RXRA (0.41) IDO1CES2ADRB1IKBKB
SCHEMBL5705364 0.67 KDM1A (0.39) KDM1A
SCHEMBL440959 0.66 CES2 (0.58) IDO1CES2ADRB1ITGB3ITGAV
SCHEMBL27995957 0.63 CES2 (0.39) IDO1CES2ADRB1ITGB3ITGAV
SCHEMBL15562144 0.63 NOTUM (0.53) IDO1CES2ADRB1
SCHEMBL4461544 0.62 CES2 (0.48) IDO1CES2ADRB1ITGB3ITGAV
SCHEMBL24118128 0.61 PTPN5 (0.48) IDO1CES2IKBKB
SCHEMBL15693716 0.61 CES2 (0.38) IDO1CES2ADRB1IKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1425318-B1 ACTIVATING ORGANOMETALLIC COMPOSITION FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS COMPRISING FLUORINATED CYCLOPENTADIENYL COMPOUNDS VERSALIS SPA (IT) 2013-01-16 EP disclosed
US-7081505-B2 Activating organometallic composition for the (co) polymerization of alpha-olefins comprising fluorinated cyclopentadienyl compounds POLIMERI EUROPA S.P.A. (IT) 2006-07-25 US disclosed
US-20040198934-A1 Activating organometallic composition for the (co) polymerization of alpha-olefins comprising fluorinated cyclopentadienyl compounds POLIMERI EUROPA S.P.A. (IT) 2004-10-07 US disclosed
EP-1425318-A1 ACTIVATING ORGANOMETALLIC COMPOSITION FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS COMPRISING FLUORINATED CYCLOPENTADIENYL COMPOUNDS Polimeri Europa S.p.A. (IT) 2004-06-09 EP disclosed
US-6596891-B1 Reaction product of fluoroorganic compound and organometallic compound ENICHEM S.P.A. (IT) 2003-07-22 US disclosed
WO-2003010210-A1 ACTIVATING ORGANOMETALLIC COMPOSITION FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS COMPRISING FLUORINATED CYCLOPENTADIENYL COMPOUNDS POLIMERI EUROPA S.P.A. (IT) 2003-02-06 WO disclosed
EP-1013675-B1 Activating composition of metallocene complexes in the catalysis of (co)polymerization processes of olefins POLIMERI EUROPA SPA (IT) 2002-07-31 EP disclosed
EP-1013675-A2 Activating composition of metallocene complexes in the catalysis of (co)polymerization processes of olefins Enichem S.p.A. (IT) 2000-06-28 EP disclosed