Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Malonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.60 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malonic Acid SCHEMBL5874133 | 1.00 | LDHA (0.60) | LDHASRRHIF1AMAPTPDE4A | |
| Malonic Acid SCHEMBL7046147 | 0.97 | LDHA (0.64) | LDHASRRHIF1AMAPTPDE4A | |
| Malonic Acid SCHEMBL6671875 | 0.87 | LDHA (0.60) | LDHASRRMAPTTSHRGABRA5 | |
| Malonic Acid SCHEMBL2950460 | 0.85 | LDHA (0.50) | LDHASRRTSHRGABRA5GABRB2 | |
| Malonic Acid SCHEMBL5874600 | 0.85 | LDHA (0.50) | LDHASRRTSHRGABRA5GABRB2 | |
| Malonic Acid SCHEMBL17371700 | 0.82 | — | — | |
| Malonic Acid SCHEMBL338744 | 0.82 | — | — | |
| Succinic Acid SCHEMBL6945727 | 0.80 | LMNA (0.60) | HIF1AMAPTPDE4AKDRTSHR | |
| Piperazine SCHEMBL8005898 | 0.80 | HIF1A (0.40) | LDHASRRHIF1AMAPTPDE4A | |
| Succinic Acid SCHEMBL5874334 | 0.80 | LMNA (0.60) | HIF1AMAPTPDE4AKDRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |