Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5874137 | 1.00 | LMNA (0.50) | LMNAEGLN1ALDH1A1ALKBH5SUCNR1 | |
| Adipic Acid SCHEMBL5874393 | 0.90 | LMNA (0.55) | LMNAALDH1A1MAPK1SLC22A6SMN1; SMN2 | |
| Adipic Acid SCHEMBL16670398 | 0.90 | LMNA (0.55) | LMNAALDH1A1MAPK1SLC22A6SMN1; SMN2 | |
| Glutarate SCHEMBL5874673 | 0.90 | SLC22A6 (0.55) | LMNAALDH1A1MAPK1SLC22A6SMN1; SMN2 | |
| Adipic Acid SCHEMBL5874403 | 0.90 | LMNA (0.55) | LMNAALDH1A1MAPK1SLC22A6SMN1; SMN2 | |
| Glutarate SCHEMBL5874662 | 0.90 | SLC22A6 (0.55) | LMNAALDH1A1MAPK1SLC22A6SMN1; SMN2 | |
| Adipic Acid SCHEMBL336949 | 0.90 | LMNA (0.55) | LMNAALDH1A1MAPK1SLC22A6SMN1; SMN2 | |
| Succinic Acid SCHEMBL8731618 | 0.88 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Adipic Acid SCHEMBL18091137 | 0.87 | LMNA (0.52) | LMNAALDH1A1MAPK1SLC22A6SMN1; SMN2 | |
| Sebacic Acid SCHEMBL5874996 | 0.87 | TSHR (0.57) | LMNAALDH1A1OR51E2SLC22A6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733956-A | COMPRISES A THERMOPLASTIC OLEFIN, A MONOMERIC AND A POLYMERIC HINDERED AMINE LIGHT STABILIZER AND AN ULTRAVIOLET LIGHT ABSORBING BENZOTRIAZOLE | SOLVAY ENGINEERED POLYMERS (US) | 1998-03-31 | — | — | US | claimed |
| CN-109306104-A | A kind of EVA intermediate coat | 刘若慧 | 2019-02-05 | — | — | CN | disclosed |
| CN-106349468-A | Preparation method of high-transparency light stabilizer 622 | 青岛文创科技有限公司 | 2017-01-25 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |