Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026596 | 0.77 | CYP1A2 (0.41) | KDM4ETSHRKMT2ACDK4CDK2 | |
| SCHEMBL6070776 | 0.71 | TP53 (0.50) | KDM4ETSHRKMT2ACDK4CDK2 | |
| SCHEMBL29198503 | 0.70 | TSHR (0.41) | KDM4ETSHRKMT2ACDK4CDK2 | |
| SCHEMBL9083175 | 0.69 | CCR2 (0.44) | KDM4ETSHRKMT2AMEN1HSD17B10 | |
| SCHEMBL5026506 | 0.68 | POLB (0.37) | KMT2ACDK4CDK2MEN1CHEK1 | |
| SCHEMBL29010524 | 0.67 | MEN1 (0.34) | KDM4ETSHRKMT2ACDK4CDK2 | |
| SCHEMBL29010536 | 0.67 | MEN1 (0.34) | KDM4ETSHRKMT2ACDK4CDK2 | |
| SCHEMBL9838267 | 0.67 | KMT2A (0.49) | KDM4ETSHRKMT2AMEN1HSD17B10 | |
| SCHEMBL11626863 | 0.67 | ALDH1A1 (0.42) | KDM4ETSHRKMT2AMEN1CYP1A2 | |
| SCHEMBL8540288 | 0.67 | DDB1 (0.36) | KMT2ACDK4CDK2MEN1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041662-B2 | Substituted benzo [b] azepin-2-one compounds | GRUNENTHAL GMBH (DE) | 2006-05-09 | — | — | US | disclosed |
| US-20040224938-A1 | Substituted benzo [b] azepin-2-one compounds | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224938-A1 | Substituted benzo [b] azepin-2-one compounds | GABARAPL2, GABBR2, GABBR1 | KDM4E 2617/4885TSHR 4537/4885KMT2A 3810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.