Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580914 | 0.96 | SLC6A4 (0.42) | SLC6A4PKMALDH1A1EPHX2APEX1 | |
| SCHEMBL586843 | 0.96 | SLC6A4 (0.47) | SLC6A4PKMMMP1ADAM17TP53 | |
| SCHEMBL587433 | 0.85 | SMN1; SMN2 (0.44) | SLC6A4MAPT | |
| SCHEMBL587349 | 0.85 | MMP1 (0.41) | SLC6A4MMP1ADAM17 | |
| SCHEMBL582439 | 0.84 | ALDH1A1 (0.36) | SLC6A4PKMALDH1A1NPSR1HPGD | |
| SCHEMBL582438 | 0.84 | ALDH1A1 (0.36) | SLC6A4PKMALDH1A1NPSR1HPGD | |
| SCHEMBL580837 | 0.84 | RIPK1 (0.41) | SLC6A4ALDH1A1EPHX2APEX1PTGS2 | |
| SCHEMBL586674 | 0.83 | NOTUM (0.44) | ALDH1A1MAPT | |
| SCHEMBL582040 | 0.82 | ALDH1A1 (0.48) | SLC6A4ALDH1A1MAPTNPSR1HPGD | |
| SCHEMBL586614 | 0.82 | ALDH1A1 (0.43) | SLC6A4PKMMMP1ADAM17TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |