Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877807 | 0.93 | F11 (0.47) | ABCC1MEN1KMT2ACRHR1 | |
| SCHEMBL5876985 | 0.91 | CRHR1 (0.44) | ABCC1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5877425 | 0.89 | CYP2D6 (0.43) | ABCC1MEN1KMT2APOLBRXFP1 | |
| SCHEMBL5877717 | 0.89 | EGFR (0.44) | ABCC1MEN1KMT2AMAPK1POLB | |
| SCHEMBL5877453 | 0.89 | CRHR1 (0.42) | ABCC1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5877228 | 0.88 | ABCC1 (0.55) | ABCC1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5878318 | 0.87 | ABCC1 (0.54) | ABCC1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5877069 | 0.87 | F11 (0.49) | ABCC1MEN1KMT2A | |
| SCHEMBL5877978 | 0.87 | AVPR1B (0.49) | ABCC1MEN1KMT2A | |
| SCHEMBL5876981 | 0.86 | F11 (0.52) | ABCC1MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |