Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877056 | 0.94 | CRHR1 (0.43) | CRHR1LMNATSHRTP53HSP90AA1 | |
| SCHEMBL5877936 | 0.91 | CRHR1 (0.41) | CRHR1LMNATSHRTP53GHSR | |
| SCHEMBL7488467 | 0.90 | CRHR1 (0.41) | CRHR1ABCC1KMT2AMEN1POLB | |
| SCHEMBL5877446 | 0.90 | CRHR1 (0.41) | CRHR1KMT2AMEN1GHSR | |
| SCHEMBL5877906 | 0.89 | ABCC1 (0.52) | CRHR1ABCC1LMNATSHRKMT2A | |
| SCHEMBL5877807 | 0.82 | F11 (0.47) | CRHR1ABCC1KMT2AMEN1GHSR | |
| SCHEMBL5877351 | 0.82 | AVPR1B (0.40) | LMNATSHRKMT2AMEN1GHSR | |
| SCHEMBL6313995 | 0.81 | RXRA (0.52) | NPC1LMNATSHRKMT2AMEN1 | |
| SCHEMBL5877228 | 0.80 | ABCC1 (0.55) | ABCC1LMNATSHRKMT2AMEN1 | |
| SCHEMBL5876985 | 0.80 | CRHR1 (0.44) | CRHR1ABCC1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |